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Abstract
In past few decades numerous studies have been conducted to explore the nature’s gift of invaluable medicinal compounds. Herbs and botanicals have been extensively reviewed by researchers worldwide. However, the bioavailability of natural compounds is still under question. Various techniques are employed to overcome the same of which phytosomes technology appears to be very promising. Phytosomes have shown marked enhancement in bioavailability and established clinical efficacy. This is due to increased solubilization of drug in intestinal milieu along with the ability to cross lipoidal biomembranes. This literature reviews the basics for preparation, mechanism of drug-phospholipid complexation and subsequent utilisation. Some of the major herbal extracts which have shown proven improvement in bioavailability are also studied. In vitro lipid digestion model is assessed which provides an indication for the in vivo performance of the commercial product. Various marketed products and leading marketing companies are also surveyed.