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Abstract
The present study was focused upon emancipating the efficacy of aqueous extract of Ipomoea batatas in abatement of bisphenol A (BPA)-induced experimental testicular toxicity. In vivo strategy of the present analysis encompasses intoxication of reproductive toxicant bisphenol A to adult male Sprague Dawley rats. Adult male Sprague Dawley rats were divided into four groups. Group I: Control, Group II: BPA-induced testicular toxicity rats (200 mg/kg body weight/day orally for 30 days), Group III: BPA-induced rats were treated with aqueous extract of I. batatas (400 mg/kg body weight/day orally for 45 days), Group IV: Normal rats treated with I. batatas aqueous extract (400 mg/kg body weight/day orally for 45 days). Marker enzymes, lipid peroxidation, and reactive oxygen species levels were found to be raised in BPA-induced testicular toxicity. Conversely, enzymatic and non-enzymatic antioxidants, mitochondria TCA cycle enzymes levels were significantly reduced. Histological changes in testis of rats induced with BPA showed severe damage within the seminiferous tubules and spermatogenic vascular degeneration and harm in cytoplasm of sertoli cells. The treatment with I. batatas tubers aqueous extract normalized the altered levels of marker enzymes, lipid peroxidation, reactive oxygen species, mitochondrial TCA cycle and antioxidants enzymes as wells as histopathological changes caused by BPA. It is concluded from the present study that I. batatas tubers may play a significant role in the management of male reproductive toxicity by antioxidant capabilities, preventing morphological modifications and escalating defense mechanism, thereby reducing oxidative stress medicated damage.