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Abstract
Advanced glycation end products (AGEs) formation is associated with different pathophysiological conditions, including diabetes mellitus. Our study aimed at screening the effect of 80 % aqueous methanol extract of leaves (AQME) of three commercial varieties of Morus indica (G4, V1 and S36) and two wild varieties of Morus sp., (Morus laevigata - ML and Morus serrata-MS) on in vitro protein glycation in BSA-glucose model. G4 exhibited the highest AGEs inhibition and metal ion chelation. It also inhibited cross-linking of protein glycation and protein aggregation. The G4 extract had a total polyphenol content of 96 mg GAE g-1 and flavonoid content of 55.3 mg CE g-1. C-glycosyl flavonoids were identified and quantified in G4 by UPLC/MS. This is the first study reporting the presence of luteolin (258 μg g-1) and apigenin (164 μg g-1) in G4 variety which possess the most active anti-glycation property. Thus, G4 could be protective against hyperglycemia-mediated protein damage.