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Abstract
Silver nanoparticles (AgNPs) were prepared using the poly phenol rich ethyl acetate fraction of Terminalia bellirica fruit pericarp and characterized by UV-Vis and infrared spectroscopy, X-ray diffraction and transmission electron microscopy. The synthesized nanoparticles had sizes in between 7-11 nm, were spherical in shape, nearly monodispersed, without aggregation and with crystalline nature. Liquid chromatography coupled with mass spectroscopy (LC-MS) studies revealed that gallic acid and ellagic acid were the major polyphenols in the ethyl acetate fraction. Infrared spectroscopy confirmed the involvement of phenolic and carboxylate groups in the reduction and stabilizing of nanoparticles. The obtained nanoparticles at a concentration of 120 μg/ml caused 69.1 and 65.2% cell death to colon cancer (HCT-15) and breast cancer cells (MCF-7) respectively and they were non-toxic to normal cardiac and skeletal muscle cells. Over all results showed that the method developed here was relatively very fast and does not required any specific condition, external reducing and stabilizing agents.