Potentiation of the Antibiotic Activity by the Essential Oils of Eugenia brasiliensis Lam. and Piper mosenii C. DC.

Rakel Olinda Macedo da Silva1 Department of Biological Chemistry, Regional University of Cariri - URCA, Crato, Brazil;2 Department of Biomedicine, University Center Dr. Leão Sampaio, Juazeiro do Norte, Brazil

Maria Karollyna do Nascimento Silva Leandro1 Department of Biological Chemistry, Regional University of Cariri - URCA, Crato, Brazil;2 Department of Biomedicine, University Center Dr. Leão Sampaio, Juazeiro do Norte, Brazil

Ana Carolina Justino de Araújo1 Department of Biological Chemistry, Regional University of Cariri - URCA, Crato, Brazil

José Walber Gonçalves Castro2 Department of Biomedicine, University Center Dr. Leão Sampaio, Juazeiro do Norte, Brazil

Orlando de Menezes Dantas Junior2 Department of Biomedicine, University Center Dr. Leão Sampaio, Juazeiro do Norte, Brazil

Raíra Justino Oliveira Costa2 Department of Biomedicine, University Center Dr. Leão Sampaio, Juazeiro do Norte, Brazil

Luciely Leite Pinto2 Department of Biomedicine, University Center Dr. Leão Sampaio, Juazeiro do Norte, Brazil

Jaime Ribeiro-Fil-ho4 Gonçalo Moniz Institute (IGM), Oswaldo Cruz Foundation, (FIOCRUZ), Salvador, Brazil

Luiz Everson da Silva5 Federal University of Paraná - UFPR, Curitiba, Brazil

Wanderlei do Amaral5 Federal University of Paraná - UFPR, Curitiba, Brazil

Cícero Deschamps5 Federal University of Paraná - UFPR, Curitiba, Brazil

Edinardo Fagner Ferreira Matias3 Postgraduate Center Caririense - CECAP, Juazeiro do Norte, Ceara, Brazil

Henrique Douglas Melo Coutinho1 Department of Biological Chemistry, Regional University of Cariri - URCA, Crato, BrazilCorrespondence[email protected]

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Abstract

The present study aimed to investigate the antibiotic-enhancing activity of the essential oils obtained from the leaves of Eugenia brasiliensis Lam (EOEb) and Piper mosenii C. DC. (EOPm) against multiresistant strains of Escherichia coli 06 and Staphylococcus aureus 10. The essential oils were obtained by hydrodistillation, and the minimum inhibitory concentrations (MIC) were determined through the broth microdilution method. The EOEb enhanced the activities of norfloxacin and erythromycin against Staphylococcus aureus and Escherichia coli, respectively. At the same conditions, the EOPm was found to potentiate the effects of gentamicin and erythromycin against E. coli. Of note, this is the first study to date that has reported the ability of these extracts to enhance the antibacterial activity of conventional antibiotics.

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Potentiation of the Antibiotic Activity by the Essential Oils of Eugenia brasiliensis Lam. and Piper mosenii C. DC.

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Potentiation of the Antibiotic Activity by the Essential Oils of Eugenia brasiliensis Lam. and Piper mosenii C. DC.

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