Immunomodulatory and cytotoxic effects of bergenin and cinchonain Ia isolated from Peltophorum pterocarpum

Trinh Thi Thuy1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam;2 Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam

Ba Thi Cham1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam;2 Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam

Nguyen Thi Thu Hoa1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam;3 Vietnam National University of Agriculture, Trau Quy, Gia Lam, Hanoi, 10072, Vietnam

Nguyen Thi Hoang Anh1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam;2 Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam

Le Thi Hong Nhung4 Hanoi University of Industry, Cau Dien, Nam Tu Liem, Hanoi, 10000, Vietnam

Do Thi Thao1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam;5 Institute of Biotechnology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam

Domenico V Delfino6 Master in Musculoskeletal and Rheumatology Physiotherapy, Department of Medicine and Surgery, University of Perugia, 06132, Italy

Nguyen Thi Thuy Linh1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, Vietnam;2 Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10000, VietnamCorrespondence[email protected]

show all

Abstract

This paper reports for the first time the immunomodulatory and cytotoxic effects of two previously isolated compounds from the stem of Peltophorum pterocarpum and characterized as bergenin (1) and cinchonain Ia (2). The immunomodulatory capacity of these two compounds was assessed based on their ability to inhibit IL-2 release from RAW264.7 cells. The results demonstrated that cinchonain Ia (2) possesses distinctly immunomodulatory effects in vitro since this compound strongly inhibited IL-2 cytokine level (at concentrations of 4.0 and 0.8 μg/mL) (P<0.01 and P<0.05), while it was increased up to 8.84 time at the 100 μg/mL concentration. Additionally, compound 2 showed a weak cytotoxic effect against 5 human cancer cells (A549, Huh-7, T24, 8505, and SNU-1) with the IC₅₀ values between 39.19 g/mL and 60.44 μg/mL.

GRAPHICAL ABSTRACT

Keywords:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Immunomodulatory and cytotoxic effects of bergenin and cinchonain Ia isolated from Peltophorum pterocarpum

Information for

Open access

Opportunities

Help and information

Immunomodulatory and cytotoxic effects of bergenin and cinchonain Ia isolated from Peltophorum pterocarpum

Abstract

GRAPHICAL ABSTRACT

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature