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Summary
Two patients with the « POEMS syndrome » are described. This unique syndrome consists of polyneuropathy, osteosclerosis, endocrinopathy, monoclonal protein and skin changes.
The pathophysiology is unknown; the plasma cell dyscrasia is essential, the secondary manifestations are unexplained.
Therapy must be directed against the plasma cell dyscrasia (radiotherapy in case of solitary plasmacytoma, or corticosteroids and cytotoxic agents) with mean survival of patients of about 33 months.