Understanding the role of genetic susceptibility (ACE2 and TMPRSS2) in COVID-19

ABSTRACT

COVID-19-related morbidity and mortality are significantly increased with increasing age and the presence of co-existing health conditions, such as cancer and cardiovascular disease. While most infected people recover, even very young and otherwise healthy patients may unpredictably succumb to this disease. COVID-19 is highly susceptible to Angiotensin-converting enzyme 2 (ACE2) and Transmembrane protease-serine 2 (TMPRSS2) polymorphisms altering the angiotensinogen-ACE2 interactions, such as p. Arg514Gly and its prevalence. The article describes the role of understanding the genetic basis of COVID-19 and its susceptibility to human genes.

KEYWORDS:

• Genetics
• susceptibility
• COVID-19
• ACE2
• TMPRSS2

Disclosure statement

No potential conflict of interest was reported by the author(s).

Authors contribution

Conceptualization, Project Administration, Writing Original draft, Writing Review, and Editing are done by Abdullahi Tunde Aborode; Sherifdeen Bamidele Onigbinde; Khadijah Sanusi Omoshalewa; Noah Alaba; Aderinola H. Rasaq-Lawal; Babatunde Samuel Obadawo; Allison Olatoyosi; Saidat Adeniran-Obey Omowunmi; Victor Onwukwe; Uchenna Asogwa; Ridwan Iyanu Arinola; Seun Idowu Imani; Ayoola S. Fasawe; Sodiya Ibukunoluwa; Sherif Babatunde Adeyemi; Gaber El-Saber Batiha. Abdullahi Tunde Aborode; Babatunde Samuel Obadawo; Allison Olatoyosi; Saidat Adeniran-Obey Omowunmi; Victor Onwukwe; Uchenna Asogwa; Ridwan Iyanu Arinola; Seun Idowu Imani; Ayoola S. Fasawe; Sodiya Ibukunoluwa; Sherif Babatunde Adeyemi; Gaber El-Saber Batiha contributed equally to the second revision and review of this article. All authors revised and approved the final draft.

Ethical statements

This article does not contain any studies with human participants or animal use.

Additional information

Funding

This research received no external funding.