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Research Article

Cerebral perfusion and its association with serum endothelin-1 in multiple sclerosis

, , ORCID Icon &
Pages 296-307 | Received 31 Jul 2021, Accepted 24 May 2022, Published online: 27 Jun 2022
 

ABSTRACT

Multiple sclerosis (MS) is a chronic inflammatory, demyelinating and degenerative disease of the central nervous system. The exact pathogenesis of MS is incompletely understood. Cerebral vascular pathology is frequently verified in this disease. Perfusion studies may put light on the disease pathogenesis. In this study, we use dynamic susceptibility contrast-enhanced perfusion magnetic resonance imaging (DSC-MRI) to evaluate the cerebral perfusion in a group of MS patients. Thirty patients with relapsing–remitting multiple sclerosis (RRMS) and 20 healthy controls were investigated. The perfusion parameters were assessed for normal-appearing white matter (NAWM) and deep gray matter (DGM). Also, the serum level of the potent vasoconstrictor, endothelin-1(ET-1), was evaluated. There was reduction in cerebral perfusion in MS patients in comparison to healthy controls in the NAWM and (DGM). In addition, serum (ET-1) level was significantly elevated in the patient group and was correlated with the perfusion parameters. These findings suggest that cerebral hypoperfusion may play an important role in the pathogenesis of MS lesions. ET-1 has a role in cerebral hypoperfusion in both NAWM and DGM of RRMS patients. DSC-MRI could be an applicable objective measure to detect cerebral hemodynamic changes in MS.

List of abbreviations

MS=

multiple sclerosis

CBF=

cerebral blood flow

CBV=

cerebral blood volume

MTT=

mean transit time

NAWM=

normal appearing white matter

DGM=

deep gray matter

CIS=

clinically isolated syndrome

RRMS=

relapsing-remitting MS

SPMS=

secondary progressive MS

ET-1=

endothelin-1

DSC-MRI=

dynamic susceptibility contrast enhanced perfusion magnetic resonance imaging

EDSS=

Expanded Disability Status Scale

ROI=

the regions of interest

CCT=

cerebral circulation time

NO=

nitric oxide.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Availability of data and materials

The datasets used during the current study are available from the corresponding author on reasonable request.

Additional information

Funding

Authors did not receive any funding for this research.