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ABSTRACT
Changes over time in information processing speed and executive functions (EFs) were studied in patients with suspected low-grade gliomas (LGG) 3 years after diagnosis. Using a person-oriented approach, the study aimed at focusing solely on two cognitive domains known to be significant in the understanding of the impact of white matter diseases. The Barkley’s hybrid model of EFs was used as a theoretical framework for the evaluation of EFs. The majority of the patients showed a decline in at least one of these two cognitive domains indicating that the progress of diffuse brain injury cannot be neglected in understanding neuropsychological changes over time in patients with LGG. In our sample, higher age and radiological signs of radiotherapy-induced brain atrophy were seen in patients with a decline in both domains.
Acknowledgments
We are grateful to all the patients and controls who willingly and kindly participated in the study. The financial support provided by the Research Committee at the Örebro University Hospital and the Regional Research Council of the Uppsala-Örebro region is greatly appreciated. We are also grateful to Professor Anja Smits at the Department of Neurology in Uppsala for her contribution to this study. Without her support and effort we would not have been able to conduct and complete the study. Our sincere thanks also go to Dr. Susann Ullén at University hospital Skåne for her invaluable assistance with statistical advice and testing. Finally, we would like to extend our thanks to Dr. Kristina Hallind and Rose Reddy for their contributions. We are grateful to the editor of Applied Neuropsychology: Adult and the anonymous reviewers for important advices during the revision process.