Inclusion of Essential Universal Health Coverage Services in Essential Packages of Health Services: A Review of 45 Low- and Lower- Middle Income Countries

ABSTRACT

Expanding service coverage and achieving universal health coverage (UHC) is a priority for many low- and middle-income countries. Though UHC is a long-term goal, its importance and relevance have only increased since the start of the COVID-19 pandemic. The first step on the road to UHC is to define and develop essential packages of health services (EPHSs), a list of clinical and public health services that a government has deemed a priority and is to provide. However, the nature of these lists of services in low- and lower-middle-income countries is largely unknown. This study examines the contents of 45 countries’ EPHSs to determine the inclusion of essential UHC (EUHC) services as defined by the Disease Control Priorities, which comprises 21 specific essential packages of interventions. EPHSs were collected from publicly available sources and their contents were analyzed in two stages, firstly, to determine the level of specificity and detail of the content of EPHSs and, secondly, to determine which essential UHC services were included. Findings show that there are large variations in the level of specificity among EPHSs and that though EUHC services are included to a large extent, variations exist regarding which services are included between countries. The results provide an overview of how countries are designing EPHSs as a policy tool and are progressing toward providing a full range of EUHC services. Additionally, the study introduces new tools and methods for UHC policy analysts and researchers to study the contents of EPHSs in future investigations.

KEYWORDS:

• Disease Control Priorities third edition
• essential package of health services
• packages of interventions
• primary health care
• universal health coverage

Introduction

Through the adoption of the Sustainable Development Goals the world’s countries have committed to achieving universal health coverage (UHC) by 2030. Globally, UHC coverage improved from 2000 to 2017 as illustrated by the UHC service coverage index.¹ However, low-income countries (LICs) still have the smallest share of people covered by essential health services, and lower-middle-income countries (LMICs) have the largest number of people who still lack coverage.¹ To achieve UHC, policymakers have to determine how to allocate resources for health efficiently and equitably. Essential packages of health services (EPHSs), defined as “a list of clinical and public health services that a government has determined as priority for the country … that the government is providing or aspiring to provide”^2(p2) have been regarded as a useful mechanism to prioritize resources for health on the grounds of effectiveness and relative cost, increasing equity, reducing poverty, and political empowerment and accountability.³ EPHSs have also been said to be an essential element in the creation of a sustainable and effective system of UHC.^4,5 For LICs and LMICs, EPHSs that are made available to all, regardless of ability to pay, have been described as a pathway to UHC.⁶

The World Bank’s Disease Control Priorities third edition (DCP3) provides a standard that countries can follow when determining which health services to include in their EPHSs. In particular, the DCP3 defines a model of essential UHC (EUHC), comprising 21 essential packages of interventions (POIs) that each address the concerns of a particular health area through a mix of intersectoral policies and health sector interventions (Table 1).⁷ The DCP3 EUHC model can inform program design when services and resources are being allocated. Designed to be acquired at an early stage of countries’ pathways to UHC, as well as having proven to be effective and cost-effective in low-resource settings,⁸ the POIs include interventions that are context specific and can be prioritized by countries as they develop their EPHSs and progress toward achieving UHC. Collectively, the POIs consist of 218 interventions, systematically selected using criteria of value for money, disease burden addressed, and implementation feasibility.⁷ A subset of 108 of these interventions forms a highest priority package (HPP) based on more stringent criteria. Though the costs estimated for HPP and EUHC are substantial, the incremental annual cost per person of the HPP is 26 USD, which has been deemed to be affordable for low-income countries.⁸ Other frameworks, such as the UHC service coverage index and the UHC Compendium,⁹ also delineate UHC services and interventions to progress toward UHC. However, the UHC service coverage index’s 14 tracer indicators, which fall under four essential health service areas, have been said to “not serve as a complete or exhaustive list of health services and interventions covered in a given country’s UHC programmes.”^1(p14) The World Health Organization’s UHC Compendium takes a comprehensive approach but is still not complete. Interventions in program areas such as child health and primary care are still being developed,⁹ making it difficult to apply for a comprehensive review.

Table 1. List of DCP3 POIs⁷

Age-related cluster (packages 1–5) Maternal and newborn health Child health School-age health and development Adolescent health and development* Reproductive health and contraception Infectious diseases cluster (packages 6–10) (6) HIV and sexually transmitted infections (7) Tuberculosis (8) Malaria and adult febrile illness (9) Neglected tropical diseases (10) Pandemic and emergency preparedness* Noncommunicable diseases and injury cluster (packages 11–17) (11) Cardiovascular, respiratory, and related disorders (12) Cancer (13) Mental, neurological, and substance use disorders (14) Musculoskeletal disorders* (15) Congenital and genetic disorders (16) Injury prevention* (17) Environmental improvements* Health services cluster (packages 18–21) (18) Surgery (19) Rehabilitation* (20) Palliative care and pain control (21) Pathology*

*Not included at the primary health care level in the DCP3 HPP.

The extent to which essential UHC services are included in country EPHSs is largely unknown. Previous studies have examined the contents of EPHSs using reproductive, maternal, newborn, and child health (RMNCH)² and sexual and reproductive health and rights¹⁰ perspectives. Previous research has also examined countries’ provision of UHC services,¹¹ essential service coverage,¹² and the process and methods used to develop EPHSs.^13,14 Though studies have noted that EPHSs vary across countries, not only in terms of their content and design¹⁵ but also in terms of their specificity, intention, purpose, and scope across countries,^2–4 studying the content of EPHSs from a UHC lens has often been overlooked. The purpose of this study is to provide a better understanding of the inclusion of essential UHC services in EPHSs in low- and lower-middle-income countries based on the DCP3 model within a larger selection of countries. We examine the specificity of EPHSs’ contents to understand how countries are defining and designing their EPHSs as a policy tool, and we examine the comprehensiveness EPHSs to provide an overview of how countries are progressing toward offering a full range of essential UHC services from the HPP in their policies.

Material and Methods

Data Sources and Collection

Our study includes all 31 LICs and the 20 most populous LMICs, as classified by the World Bank country income classification.¹⁶ The countries included face the greatest challenges in terms of disease burden and effective mobilization of and use of resources.¹⁷ Data for six countries could not be located, and so the final data set consisted of 45 EPHSs in the form of government documents (see Table A1 for details on documents included in the analysis). Data were collected in January and February 2020 from publicly available sources through an exhaustive Internet search by searching the websites and databases of government agencies, such as the Ministry of Health, as well as other relevant organizations to obtain primary data (i.e., government policy documents). Most EPHSs, defined in this study as a list of services that the government had determined as a priority or the country and are aspiring to provide, were found in documents such as health sector strategic plans, health development plans, and national health policies. Search terms used to locate countries’ EPHSs used a combination of keywords and phrases that included, but were not limited to, “essential package of health services,” “essential health service package,” “basic health service package,” “minimum health package,” “national health service package,” “essential universal health coverage package,” and “universal health coverage package.” This study focuses on the primary health care (PHC) level because achieving UHC is contingent on prioritizing investments in PHC¹ and most resources will be needed to support services at this level.¹⁷ As such, EPHSs concerning only PHC or all levels of care were collected. EPHSs that were not in English were translated into English.

Analytical Approach

In order to better understand how the contents of low- and lower-middle-income countries’ EPHSs aligned with the DCP3’s HPP, the first objective was to categorize EPHSs based on the level of specificity and detail of their contents; that is, whether they contained a list of clinical and public health services. The second objective was to examine which essential UHC services from the HPP were included in EPHSs to identify trends and gaps. As such, the analysis was conducted in two stages: the first categorized the EPHSs based on the degree of specificity of contents, and the second matched the services in EPHSs against the DCP3 HPP packages of interventions. EPHSs were analyzed using policy content analysis, which focuses on the substance of policies.^18,19

Case Classification Scheme

The first stage of analysis was performed by reviewing the contents of EPHSs through multiple readings and categorizing them according to a case classification scheme along a spectrum of four categories: case one, case two, case three, or case four (see Figure 1). The case classification determined which EPHSs’ contents were eligible for the second level of analysis, in which the content of the EPHS would be matched and mapped against the POIs that make up the DCP3’s HPP. To be eligible for the second level of analysis, EPHSs had to clearly outline a list of clinical and public health services and be categorized as case four.

Figure 1. Case classification scheme on which EPHSs were categorized

Matching of EPHSs Against DCP3

The second stage of analysis consisted of a high-level matching performed through a second round of reviewing the EPHSs. This matching was conceptual rather than verbatim and was conducted by comparing the content of an EPHSs against the POIs that make up the DCP3’s HPP. The inclusion of POIs was evaluated by comparing and matching the list of services in EPHSs to the specific interventions under each POI (see Table A2). Only 14 out of the 21 DCP3 POIs were considered because the remaining 7 POIs do not have specific interventions that are deliverable at the PHC level through community- and health center–level platforms (see Table 1). POIs were marked as included if EPHSs contained services that explicitly or implicitly matched, or were conceptually related to, the specific interventions under each POI. EPHSs did not need to include all of the interventions contained within each POI to be marked as included in the analysis. Instead, it was sufficient for an EPHS to include one of the specific interventions from the POI. To increase reliability of the analysis, peer debriefing with two external experts was conducted. Furthermore, documents were reviewed twice to ensure dependability, and an audit trail in the form of extensive notes was kept.

Results

EPHS Case Classification

Table 2 shows the case classification of the countries studied disaggregated by country income level. Twelve percent of countries’ EPHSs did not exist or were unable to be located at the time of data collection and were thus classified as case one. One-third were classified as case two, 24% as case three, and 31% as case four.

Table 2. Case classification results disaggregated by country income level

	Case 1	Case 2	Case 3	Case 4
Low-income country	Central African Republic Syria Yemen	Benin Burkina Faso Guinea-Bissau Mozambique Nepal Somalia Tanzania Togo Uganda	Burundi Chad Eritrea Guinea Madagascar Mali Niger Tajikistan The Gambia	Afghanistan Democratic Republic of Congo Ethiopia Haiti Liberia Malawi North Korea Rwanda Sierra Leon
Lower-middle income country	Morocco Pakistan	Angola Cameroon Cote d’Ivoire Egypt Philippines Ukraine Vietnam Zambia	Myanmar Sudan Uzbekistan	Bangladesh Ghana India Indonesia Kenya Nigeria Republic of Congo

Inclusion of POIs in EPHSs

Case four EPHSs comprised 36% of the 45 EPHSs reviewed. All 16 case four EPHSs included 10 or more of the 14 POIs (see Table 3). Three (19%) of the case four EPHSs, from Ethiopia, Kenya, and Congo, included all 14 POIs. More than half (51%) of case four EPHSs included 13 or more POIs in their EPHSs. Ghana’s EPHS included the least POIs, with 10 out of 14. POIs 1, 2, 5, 6, 7, 8, and 15 were included in all case four EPHSs. POI 20 (palliative care and pain control) was included in only three (19%) of the EPHSs and was the least frequently included POI. Of all case four EPHSs, Ghana’s EPHS was the only one to not contain POI 3 (school-age health and development), and North Korea’s EPHS was the only one to not contain POI 13 (mental, neurological, and substance use disorders). As shown in Table 3, LICs included 80% of POIs in their EPHSs, whereas LMICs included 90%.

Table 3. Inclusion of the DCP3 POIs in EPHSs disaggregated by country income level

LIC

POI 1

POI 2

POI 3

POI 5

POI 6

POI 7

POI 8

POI 9

POI 11

POI 12

POI 13

POI 15

POI 18

POI 20

No. of POIs in EPHS

Ethiopia

x

x

x

x

x

x

x

x

x

x

x

x

x

x

14

Haiti

x

x

x

x

x

x

x

x

x

x

x

x

x

–

13

Liberia

x

x

x

x

x

x

x

x

x

x

x

x

x

–

13

Malawi

x

x

x

x

x

x

x

x

x

x

x

x

x

–

13

Rwanda

x

x

x

x

x

x

x

–

x

x

x

x

x

x

13

Afghanistan

x

x

x

x

x

x

x

–

x

x

x

x

x

–

12

Democratic Republic of Congo

x

x

x

x

x

x

x

x

x

–

x

x

x

–

12

Sierra Leone

x

x

x

x

x

x

x

–

x

x

x

x

x

–

12

North Korea

x

x

x

x

x

x

x

x

x

x

–

x

–

–

11

No. of countrieswith POI

9

9

9

9

9

9

9

6

9

8

8

9

8

2

LMIC

Kenya

x

x

x

x

x

x

x

x

x

x

x

x

x

x

14

Congo

x

x

x

x

x

x

x

x

x

x

x

x

x

x

14

India

x

x

x

x

x

x

x

x

x

x

x

x

x

–

13

Nigeria

x

x

x

x

x

x

x

x

x

x

x

x

x

–

13

Bangladesh

x

x

x

x

x

x

x

x

x

x

x

x

–

–

12

Indonesia

x

x

x

x

x

x

x

x

–

–

x

x

x

–

11

Ghana

x

x

–

x

x

x

x

–

–

x

x

x

x

–

10

No. of countrieswith POI

7

7

6

7

7

7

7

6

5

6

7

7

6

2

Age-related cluster

POI 1. Maternal and newborn health; POI 2. Child health; POI 3. School-age health and development; POI 4. Adolescent health and development; POI 5. Reproductive health and contraception

Infectious diseases cluster

POI 6. HIV and sexually transmitted infections; POI 7. Tuberculosis; POI 8. Malaria and adult febrile illness; POI 9. Neglectedtropical diseases

Noncommunicable diseases and injury cluster

POI 11. Cardiovascular, respiratory, and related disorders; POI 12. Cancer; POI 13. Mental, neurological, and substance usedisorders; POI 15. Congenital and genetic disorders

Health services cluster

POI 18. Surgery; POI 20. Palliative care and pain control

LIC = low-income country; LMIC = lower-middle income country; x = POI included in EPHS; – = POI not included in EPHS

Discussion

Study results show that there are large variations in how detailed EPHSs are. EPHS range from being unspecific and aspirational to explicit and operational. Within the most specific (case four) EPHSs, most DCP3 packages of interventions were included, though variations were found both across packages and between countries.

Specificity of EPHSs

Despite EPHSs being defined as a list of clinical and public health services prioritized by a government, most EPHSs in this study did not fit this definition. We found large variations in specificity and detail in how health services were described in EPHSs, corroborating previous research.^10,15,20 The appropriate level of specificity for EPHSs has been discussed in different countries and contexts. For example, in the United States, there was an extensive discussion on the level of detail of the essential benefit package as part of a health reform.²¹ After reviewing evidence, policy makers decided on a high level of specificity arguing that for contents of essential health plans to be guided by scientific evidence, there need to be specific definitions and descriptions of what is included and excluded.²¹ However, others heed that packages should compromise between generalizability and specificity to strike a balance between detail and freedom for doctors to adjust approaches and treatments for individual patients.²⁰ The range of specificity among EPHSs can be attributed to countries using them for different reasons and heterogenous policy objectives.² EPHSs’ uses range from a political instrument to mobilize resources³ and a practical tool for implementation and use²² to an accountability mechanism for citizens to be made aware of what services are available to them.⁴

Currently, there is no conceptual framework to facilitate how specific the list of services in EPHSs should be; therefore, countries must decide for themselves how to define and specify a list of clinical and public health services in their EPHSs.²⁰ This contributes to discrepancies across countries’ EPHSs, as seen in Table 2. The variation in design and specificity of EPHSs will continue to be inherent because there is a lack of consensus as to which level of specificity is optimal. This highlights the usefulness and relevance of the case classification scheme for understanding these variations and illustrates how countries have developed and use EPHSs differently as a tool to progress toward UHC.

Inclusion of Essential UHC Services from the HPP in EPHSs

We also found variations in the inclusion of essential UHC services within EPHSs. This corroborates previous research that has shown the contents of EPHSs vary between countries.^2,10,15,22 With limited available resources, trade-offs are inevitable for countries in terms of which priority disease areas and related programs are included within EPHSs.²³ Packages of interventions from the HPP have been designed with LICs’ limited resources in mind,⁷ provide value for money, and address disease burden that contributes most to impoverishment. These packages can be adopted by both LICs and LMICs that are committed to rapid improvements to population health and increase progress toward UHC.⁸ Still, 12% of POIs were not included in the sample of EPHSs analyzed. This indicates that the HPP appears to be an appropriate reference for examining and tracking the progress of the content of UHC policies in low resource settings.

Many LICs and LMICs are recipients of development assistance for health (DAH) from both public and private funders,²⁴ and though most external funders strive to align with country priorities, donors also have their own interests. Therefore, levels of DAH, and what health priorities DAH supports, can change for reasons independent of the needs in the recipient country.⁷ A challenge for LICs and LMICs moving toward UHC is that, although they have full responsibility for EPHSs, the content and priorities within these EPHSs and the resources available for implementing them are to some degree influenced by external funders and the level of DAH. As a consequence, countries that are highly dependent on DAH can find it difficult to finance an EPHS that includes all of DCP3’s POIs because development assistance for health is often fragmented and earmarked for certain purposes.²⁵

RMNCH and infectious disease POIs were included in 96% of the EPHSs analyzed, which aligns with previous findings.^2,22 The high level of inclusion of RMNCH and infectious diseases was expected because both areas account for a high burden of morbidity and mortality in LICs and LMICs.²⁶ However, the very high level of inclusion of these POIs is also a reflection of DAH priorities. The Millennium Development Goals specifically focused on RMNCH through goals four and five, and the creation of disease-specific initiatives such as the President's Emergency Plan for AIDS Relief (PEPFAR) and the Global Fund has directed resources toward communicable diseases such as AIDS, tuberculosis, and malaria.²⁴ Nevertheless, in the current Sustainable Development Goals era, RMNCH and infectious disease remain prioritized in DAH^7,24,27 and can partly explain why these POIs remain the most included in EPHSs. Countries also prioritize noncommunicable diseases (NCDs) and injury POIs in their EPHSs, despite only 2% of total DAH being allocated to NCDs in 2018.²⁷ Though NCDs account for approximately 60% of the global burden of disease²⁸ and 80% of NCD deaths occur in LMICs, donors are not coordinating their “… responses to NCDs with their responses to maternal, neonatal, and child health problems, …”^23(p305) which may explain why these POIs were not included in countries’ EPHSs to the same extent as RMNCH POIs. POI 20, palliative care and pain control, was included in only 19% of the EPHSs despite a wealth of evidence demonstrating the burden of remediable health-related suffering and the effectiveness of palliative care and pain treatment. Previous research similarly found that 74% of countries do not integrate palliative care into their mainstream service provision.²⁹ The noninclusion of this POI in the EPHSs may also be because palliative care extends beyond the health sector and necessitates intersectoral cooperation in order to meet the food, housing, and transportation needs of citizens.²³

The overview of the inclusion of essential UHC services in EPHSs seen in Table 3 indicates how countries are progressing toward offering a full range of essential services in their UHC policies. Because this study focuses on the contents of EPHSs, the study cannot speak to the implementation of EPHSs and the practicalities related to this in the field but complements research that discusses the process and methods used to develop EPHSs. Findings on the inclusion and, by extension, exclusion of services can serve as a reference for accountability and be used by civil society in advocating for governments to include services within EPHSs and to hold them accountable for their commitments.

Limitations

Because the content of a country’s EPHS can be divided across several policy documents, the review may not have completely captured the studied countries’ EPHSs. Furthermore, because contents of EPHSs were compared against and matched against the DCP3 on a conceptual level, the results may not capture all details of what is included within each package of intervention. Though the reliability of the findings is ensured by the overall approach provided by the DCP3 framework, future research could adopt a stricter approach where EPHSs are matched with all services in the POIs.

Conclusions

An Essential Package of Health Services specifying a list of services based on context-specific health needs and that accounts for cost-effectiveness and equity as well as financial risk protection can be an effective tool for advancing UHC reforms. Our review found that, although most countries have an EPHS, the majority do not specify a list of clinical and public health services that are included. This study provides an overview of the content of countries’ UHC, which is necessary when assessing how services align with burdens of disease, implementation feasibility, and cost-effectiveness. The case classification framework offers a tool for policy researchers and analysts to conceptualize and understand the variations in how countries are currently defining and designing their EPHSs differently as a policy tool.

Acknowledgments

We acknowledge valuable input on methods and analysis from Eoghan Brady and Jeanna Holtz.

Disclosure of Potential Conflicts of Interest

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

The authors reported that there is no funding associated with the work featured in this article.

Appendix

Table A1. List of countries’ essential packages of health services reviewed in analysis. All documents can be found here

Country	Title of Document	Year Published
Afghanistan	A Basic Package of Health Services for Afghanistan—2010/1389	2010
Angola	Plano Nacional de Desenvolvimento Sanitário 2012–2025, Volume 1	2012
Bangladesh	Essential Package of Health Services Country Snapshot: Bangladesh	2015
Benin	Plan National de Développement Sanitaire 2018–2022	2018
Burkina Faso	Plan National De Développement Sanitaire 2011–2020	2011
Burundi	National Health Development Plan 2011–2015	n.d.
Cameroon	Health Sector Strategy 2016–2027	n.d.
Chad	Politique Nationale de Santé	2016
Congo	Plan National de Développement Sanitaire 2018–2022	2018
Côte d’Ivore	Plan National de Developpement PND 2016–2020	2016
Democratic Republic of Congo	Essential Package of Health Services Country Snapshot: Democratic Republic of Congo	2015
Egypt	White Paper: Framing National Health Policy, Executive Summary	2014
Eritrea	Health Sector Strategic Development Plan HSSDP: 2010–2014	2010
Ethiopia	Essential Health Services Packages for Ethiopia	2019
Gambia	National Health Policy, Republic of the Gambia	n.d.
Ghana	Essential Package of Health Services Country Snapshot: Ghana	2015
Guinea	Plan National de Développement Sanitaire (PNDS) 2015–2024	2015
Guinea-Bissau	Plano Nacional de Desenvolvimento Sanitário II (PNDS II) 2008–2017	2008
Haiti	Le Paquet Essentiel de Services	2015
India	Essential Package of Health Services Country Snapshot: India	2015
Indonesia	Essential Packages of Health Services Country Snapshot: Indonesia	2015
Kenya	Kenya Health Sector Strategic and Investment Plan (KHSSP) July 2014–June 2018	2013
Liberia	Essential Package of Health Services. Primary Care: The Community Health System Phase One	2011
Madagascar	Plan de Développement du Secteur Santé 2015–2019	2015
Malawi	Health Sector Strategic Plan II 2017–2022	2017
Mali	Plan Decennal de Developpement Sanitaire et Social (PDDSS) 2014–2023	2014
Mozambique	Health Sector Strategic Plan PESS 2014–2019	2014
Myanmar	Myanmar National Health Plan 2017–2021	2016
Nepal	Nepal Health Sector Strategy Implementation Plan 2016–2021	2017
Niger	Normes et Standards du Systeme de Sante du Niger	2017
Nigeria	Second National Strategic Health Development Plan 2018–2022	2018
North Korea	Medium Term Strategic Plan for the Development of the Health Sector DPR KOREA 2016–2020	2017
Philippines	National Objectives for Health, Philippines 2017–2022	2018
Rwanda	Health Services Packages for Public Health Facilities	2017
Sierra Leone	Sierra Leone Basic Package of Essential Health Services 2015–2020	2015
Somalia	Somali Roadmap Toward Universal Health Coverage 2019–2023	2018
Sudan	National Health Sector Strategic Plan II (2012–2016)	2012
Tajikistan	National Health Strategy of the Republic of Tajikistan 2010–2020	2010
Tanzania	Health Sector Strategic Plan July 2015–June 2020	2015
Togo	Système de financement de la santé au Togo: Revue et analyze du système	2015
Uganda	Health Sector Development Plan 2015/2016–2019/2020	2015
Ukraine	Medical Guarantee Program: Implementation in Ukraine	n.d.
Uzbekistan	Uzbekistan Health Systems Review	2014
Vietnam	Plan for People’s Health Protection, Care and Promotion 2016–2020	2016
Zambia	Zambia National Health Strategic Plan 2017–2021	2017

Table A2. List of interventions within DCP3 POIs at the primary health care level in the HPP

Intervention Name	DCP Package (Package Number)
Counseling of mothers on providing thermal care for preterm newborns (delayed bath and skin-to-skin contact)	Maternal and newborn health (1)
Management of labor and delivery in low-risk women by skilled attendants, including basic neonatal resuscitation following delivery	Maternal and newborn health (1)
Tetanus toxoid immunization among schoolchildren and among women attending antenatal care	Maternal and newborn health (1) School-age health (3) Reproductive health (5)
In high malaria transmission settings, intermittent preventive treatment in pregnancy	Maternal and newborn health (1) Adult febrile illness (8)
Detection and management of severe acute malnutrition and referral in the presence of complications	Child health (2)
Detection and treatment of childhood infections, including referral if danger signs	Child health (2)
Education on handwashing and safe disposal of children’s stools	Child health (2)
Pneumococcus vaccination	Child health (2)
Rotavirus vaccination	Child health (2)
Provision of cotrimoxazole to children born to HIV-positive mothers	Child health (2)
Provision of vitamin A and zinc supplementation to children according to World Health Organization guidelines and provision of food supplementation to women and children in food insecure households	Child health (2) School-age health (3) Reproductive health (5) Cardiovascular, respiratory, and related disorders (11)
Childhood vaccination series (diphtheria, pertussis, tetanus, polio, Bacillus Calmette–Guérin, measles, hepatitis B, Haemophilus influenzae type b, rubella)	Childhood health (2) HIV/sexually transmitted infections (6) Tuberculosis (7) Cancer (12) Congenital disorders (15)
In high malaria transmission settings, indoor residual spraying in selected areas with high transmission and entomologic data on indoor residual spraying susceptibility	Child health (2) Adult febrile illness (8)
School-based human papillomavirus vaccination for girls	School-age health (3) Reproductive health (5) HIV/sexually transmitted infections (6) Cancer (12)
Mass drug administration for lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiases and trachoma, and foodborne trematode infections	School-age health (3) Neglected tropical diseases (9)
Provision of iron and folic acid supplementation to pregnant women and provision of food or caloric supplementation to pregnant women in food insecure households	Reproductive health (5) Cardiovascular, respiratory, and related disorders (11)
Community-based HIV testing and counseling (for example, mobile units and venue-based testing), with appropriate referral or linkage to care and immediate initiation of lifelong antiretroviral therapy	HIV/sexually transmitted infections (6)
Provision of condoms to key populations, including sex workers, men who have sex with men, people who inject drugs, transgender populations, and prisoners	HIV/sexually transmitted infections (6)
Provision of harm reduction services such as safe injection equipment and opioid substitution therapy to people who inject drugs	HIV/sexually transmitted infections (6) Mental health, neurological, and substance abuse (13)
In all malaria-endemic countries, diagnosis with rapid test or microscopy (including speciation) followed by treatment with artemisinin-based combination therapies (or current first-line combination)	Adult febrile illness (8)
In high malaria transmission settings where rapid tests and microscopy are unavailable, presumptive treatment of febrile illness with artemisinin-based combination therapies (nonsevere cases) or artemisinin-based combination therapies plus antibiotics (severe cases)	Adult febrile illness (8)
In high malaria transmission settings, intermittent preventive treatment in infancy (except where seasonal malaria chemoprophylaxis is being provided)	Adult febrile illness (8)
In the Sahel region, seasonal malaria chemoprophylaxis	Adult febrile illness (8)
Early detection and treatment of Chagas disease, human African trypanosomiasis, leprosy, and leishmaniases	Neglected tropical diseases (9)
Early detection and treatment of neonatal pneumonia with oral antibiotics	Maternal and newborn health (1)
Management of miscarriage or incomplete abortion and postabortion care	Maternal and newborn health (1)
Management of preterm premature rupture of membranes, including administration of antibiotics	Maternal and newborn health (1)
Provision of condoms and hormonal contraceptives, including emergency contraceptives	Maternal and newborn health (1)
Counseling of mothers on providing kangaroo care for newborns	Maternal and newborn health (1)
Management of neonatal sepsis, pneumonia, and meningitis using injectable and oral antibiotics	Maternal and newborn health (1)
Pharmacological termination of pregnancy	Maternal and newborn health (1)
Prevention of mother-to-child transmission of HIV (Option B+) and syphilis	Maternal and newborn health (1) HIV/sexually transmitted infections (6) Congenital disorders (15)
Management of labor and delivery in low-risk women (basic emergency obstetric and neonatal care), including initial treatment of obstetric or delivery complications prior to transfer	Maternal and newborn health (1) Surgery (18)
Detection and treatment of childhood infections with danger signs	Child health (2) HIV (6)
Among all individuals who are known to be HIV positive, immediate antiretroviral therapy initiation with regular monitoring of viral load for adherence and development of resistance	Child health (2) HIV/sexually transmitted infections (6)
Post-gender-based violence care, including counseling, provision of emergency contraception, and rape response referral (medical and judicial)	Reproductive health (5) HIV/sexually transmitted infections (6)
Syndromic management of common sexual and reproductive tract infections (for example, uretheral discharge, genital ulcer, and others) according to World Health Organization guidelines	Reproductive health (5) HIV/sexually transmitted infections (6)
Provider-initiated testing and counseling for HIV, sexually transmitted infections, and hepatitis for all in contact with the health system in high prevalence settings, including prenatal care with appropriate referral or linkage to care including immediate antiretroviral therapy initiation for those testing positive for HIV	HIV/sexually transmitted infections (6)
Provision of voluntary medical male circumcision in settings with high prevalence of HIV	HIV/sexually transmitted infections (6) Surgery (18)
Diagnosis of tuberculosis, including assessment of rifampicin resistance using rapid molecular diagnostics (UltraXpert), and initiation of first-line treatment per current World Health Organization guidelines for drug-susceptible tuberculosis; referral for confirmation, further assessment of drug resistance, and treatment of drug-resistant tuberculosis	Tuberculosis (7)
Screening for HIV in all individuals with a diagnosis of active tuberculosis; if HIV infection is present, start (or refer for) antiretroviral treatment and HIV care	Tuberculosis (7)
Evaluation and management of fever in clinically stable individuals using World Health Organization integrated management of adolescent and adult illness guidelines, with referral of unstable individuals to first-level hospital care	Adult febrile illness (8)
Provision of aspirin for all cases of suspected acute myocardial infarction	Cardiovascular, respiratory, and related disorders (11)
Screening and management of diabetes among at-risk adults, including glycemic control, management of blood pressure and lipids, and consistent foot care	Cardiovascular, respiratory, and related disorders (11)
Secondary prophylaxis with penicillin for rheumatic fever or established rheumatic heart disease	Cardiovascular, respiratory, and related disorders (11)
Treatment of acute pharyngitis in children to prevent rheumatic fever	Cardiovascular, respiratory, and related disorders (11)
Long-term management of ischemic heart disease, stroke, and peripheral vascular disease with aspirin, beta blockers, angiotensin-converting enzyme inhibitors, and statins (as indicated) to reduce risk of further events	Cardiovascular, respiratory, and related disorders (11)
Medical management of heart failure with diuretics, betablockers, angiotensin-converting enzyme inhibitors, and mineralocorticoid antagonists	Cardiovascular, respiratory, and related disorders (11)
Essential palliative care and pain control measures, including oral immediate-release morphine and medicines for associated symptoms	Cancer (12) Palliative care (20)
Management of bipolar disorder using generic mood-stabilizing medications and psychosocial treatment	Mental health, neurological, and substance abuse (13)
Management of depression and anxiety disorders with psychological and generic antidepressant therapy	Mental health, neurological, and substance abuse (13)
Management of epilepsy, including acute stabilization and long-term management with generic anti-epileptics	Mental health, neurological, and substance abuse (13)
Management of schizophrenia using generic antipsychotic medications and psychosocial treatment	Mental health, neurological, and substance abuse (13)
Drainage of superficial abscess	Surgery (18)
Resuscitation with basic life support measures	Surgery (18)