Evaluation of phytochemical content, antioxidant, antimicrobial activity and DNA cleavage effect of endemic Linaria corifolia Desf. (Plantaginaceae)

Abstract

The aim of this study is to isolate Linaria corifolia Desf. (Plantaginaceae) and identify new apigenine derivatives 6,3′-dimethoxyapigenin-7-O-[(rhamnosyl)-(1–2)-6″-acetyl glucoside]. Moreover, we analyzed biological activity and flavonoids by using HPLC methods from extracts. The L. corifolia Desf. samples were collected in Black Sea Region of Turkey. Ethanol (EtOH), ethyl acetate (EtOAc) and dichloromethane (DCM) extracts in aerial and under solid parts of plant were evaluated for antioxidant, antimicrobial activity and effect of DNA cleavage. Quercetin, gallic acid and catechin as flavonoids were identified in EtOH, EtOAc, DCM extracts.

Keywords:

• Linaria corifolia Desf.
• antioxidant activity
• antimicrobial
• DNA cleavage effect

Public Interest Statement

• General aspects of endemic Linaria corifolia Desf. (Plantaginaceae).

• Antioxidant and antimicrobial properties of soil and under soil part extracts and volatile oil.

• Some flavonoids determination via HPLC.

• Isolated new apigenin derivatives.

Acknowledgments

The authors wish to thank Prof Dr Gulactı TOPCU, from the University of Bezmialem (Istanbul, Turkey) for the help in identification of Compound 1 NMR. All samples identified in the AUMAULAB central Laboratory in Amasya University in Turkey. I wish to thank all AUMAULAB staff for their very meticulous work.

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Source: Authors.

Additional information

Notes on contributors

Melek Gul

Melek Gul was responsible for acquisition of data, conception and design of study, analysis and/or interpretation of data and drafting the manuscript Gul performed analysis on all samples, and acted as corresponding author. Gul isolated new apigenin derivative by HPLC analysis andantioxidant test was made.

Ilkay Ozturk Cali

Ilkay Ozturk Cali helped in collecting plant material and evaluation.

Arzu Cansaran

Arzu Cansaran aided in classifying the collected plant material and prepared plant material for use chemical analysis.

Onder Idil

Onder Idil perfomed antimicrobial analysis (Acquisition of data, analysis and/or interpretation of data).

Irem Kulu

Irem Kuluhelped in essential oil analysis, determined antioxidant properties (Acquisition of data, Analysis and/or interpretation of data).

Umut Celikoglu

Umut Celikogluperformed DNA-intraction effect (Acquisition of data, Analysis and/or interpretation of data).

All authors who have made additive to the work reported in the manuscript (e.g. experimentally help, writing, conception and design of study, acquisition of data), but who do not meet the criteria for authorship, as Prof Dr Gülaçtı TOPÇU is named in the Acknowledgements.