Functional versus non-functional intratumor heterogeneity in cancer

Marc J. WilliamsEvolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, London, UK;Department of Cell and Developmental Biology, University College London, London, UK.;Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College, London, UKCorrespondence[email protected] [email protected]

Benjamin WernerCentre for Evolution and Cancer, The Institute of Cancer Research, London, UKCorrespondence[email protected] [email protected]

Trevor A. GrahamEvolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, London, UK

Andrea SottorivaCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK

ABSTRACT

Next-generation sequencing data from human cancers are often difficult to interpret within the context of tumor evolution. We developed a mathematical model describing the accumulation of mutations under neutral evolutionary dynamics and showed that 323/904 cancers (∼30%) from multiple types were consistent with the neutral model of tumor evolution.

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Functional versus non-functional intratumor heterogeneity in cancer

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Functional versus non-functional intratumor heterogeneity in cancer

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