CDK4, a new metabolic sensor that antagonizes AMPK

ABSTRACT

Cyclin-dependent kinase 4 (CDK4) is a positive regulator of cell cycle progression, however, there is growing evidence demonstrating that its function exceeds the control of cell division. Here we show that CDK4 is an important regulator of cellular substrate utilization through direct inhibition of the metabolic regulator AMPK (AMP-activated protein kinase).

KEYWORDS:

• Cell Cycle
• Metabolism
• CDK4
• Fatty acid oxidation
• AMPK
• Tumor metabolism

Acknowledgments

We thank Albert Giralt for his critical reading of this manuscript.

Funding

This work was supported by the Swiss National Science Foundation.