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ABSTRACT
Starvation causes reductions in plasma leptin concentrations, but the physiologic impact of this observation had not been documented in the starved state. Here we discuss our recent work demonstrating that hypoleptinemia activates the hypothalamic-pituitary-adrenal (HPA) axis, increasing white adipose tissue (WAT) lipolysis and mediating a shift from glucose to fat metabolism to maintain euglycemia in fasted rats.
Disclosure of potential conflicts of interest
No potential conflicts of interest were disclosed.
Additional information
Funding
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) HHS | NIH | National Cancer Institute (NCI).