A balancing act: mTOR integrates nutrient signals to regulate redox-dependent growth and survival through SOD1

ABSTRACT

Maintaining cellular redox is critical for growth, metabolism and survival in response to changing environments. How nutrients regulate this process is a long-standing fundamental question in cell biology. Our recent study revealed a conserved mechanism by which eukaryotes, particularly cancer cells, couple nutrient signaling to dynamically regulate redox homeostasis.

Abbreviations: ATP: adenosine triphosphate; Ala: alanine; C₆H₁₂O₆: glucose; OH⁻: hydroxyl radical; Glu: glutamate; mRNA: messenger RNA; mTOR: mechanistic/mammalian target of rapamycin; OXYPHOS: oxidative phosphorylation; Ser: serine; ROS: reactive oxygen species; O₂⁻: superoxide; SOD1: superoxide dismutase 1; Thr: threonine

Keywords:

• mTOR
• SOD1
• ROS
• nutrient
• ischemia

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Additional information

Funding

This work was supported by the National Institutes of Health [R01CA166575];National Institutes of Health [R01CA123391];