http://orcid.org/0000-0002-5876-9969
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ABSTRACT
Extracellular signal-regulated kinase (ERK) plays a critical role in tissue homeostasis and tumorigenesis. By utilizing live imaging approaches, we recently uncovered ERK activity dynamics in the intestinal epithelium. Notably, we showed that ERK activity dynamics are defined by composite regulation from two distinct upstream receptors, and alteration of their functional balance underlies tumor cell-specific traits. Here, we discuss these findings.
Acknowledgments
We are grateful to the Medical Research Support Center of Kyoto University for technical assistance.
Disclosure of potential conflicts of interest
No potential conflicts of interest were disclosed.
Additional information
Funding
M.I. was supported by the Takeda Science Foundation and Japan Society for the Promotion of Science (JSPS) (Grant-in-Aid for Scientific Research (KAKENHI) on Innovative Areas, “Integrated analysis and regulation of cellular diversity” (18H05100) and for Scientific Research (C) (18K06929)). M.M. was supported by the Nakatani Foundation, CREST JPMJCR1654 and JSPS KAKENHI Grant Numbers 15H02397, 15H05949 “Resonance Bio”, and 16H06280 “ABiS”.