DNA repair synthesis and histone deposition partner during homologous recombination

ABSTRACT

Chromatin remodeling is critical for the regulation of the DNA damage response. We highlight findings from our recent study showing that the deposition of the histone variant H3.3 by the alpha-thalassemia mental retardation X-linked protein (ATRX) and the death domain associated protein (DAXX) chromatin remodeling complex regulates DNA repair synthesis during homologous recombination.

Keywords:

• Double-strand breaks
• homologous recombination
• repair synthesis
• chromatin remodeling
• ATRX
• DAXX
• H3.3

Disclosure of interest

The authors report no conflict of interest.

Additional information

Funding

This work was supported by the Deutsche Forschungsgemeinschaft (GRK1657) and the Bundesministerium für Bildung und Forschung (02NUK037C).