Tracking tumor evolution one-cell-at-a-time

ABSTRACT

Accumulating evidence suggests that intra-tumor heterogeneity (ITH) within tumor sub-populations is a major contributor to therapy resistance, with genomically distinct clonal populations exhibiting different therapeutic vulnerabilities. Here we employed single-cell transcriptomics in patient-derived primary cells to understand the impact of phenotypic intra-tumor heterogeneity on drug-induced tumor evolution in oral squamous cell carcinoma.

KEYWORDS:

• Single cell RNA-seq
• tumor evolution
• epigenetic plasticity
• drug-resistance
• cancer stem cells

Additional information

Funding

This work was supported by the A-star [Core funds].