https://orcid.org/0000-0002-6732-4216
![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
ABSTRACT
Endocytic trafficking has emerged as an essential mechanism to spatiotemporally coordinate signaling protein complexes that control cytoskeletal dynamics and cell motility. Our study established an unexpected regulatory mechanism whereby ADP ribosylation factors 6 (ARF6) controls the stability and endosomal localization of RAS homologous protein B (RHOB) to regulate cell invasion downstream of the oncogenic receptor tyrosine kinase, MET.
Disclosure of potential conflicts of interest
No potential conflicts of interest were disclosed.
Additional information
Funding
This research was supported by a Susan G. Komen for the Cure Postdoctoral fellowship (KG111467) to K. Zaoui and a Canadian Institutes of Health Research Foundation grant (242529) to M. Park. M. Park holds the Diane and Sal Guerrera Chair in Cancer Genetics.