Clinical efficacy of amoxicillin/clavulanate plus cefditoren as de-escalation combination therapy for endocarditis due to strongly biofilm-forming Enterococcus faecalis

Vittorio AttanasioFirst division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Naples, Italy;

Mariagrazia Di LucaDepartment of Biology, University of Pisa, Pisa, Italy;

Antonio CarozzaUOSD Advanced Techniques in Cardiosurgery, Monaldi Hospital, AORN dei Colli, Naples, Italy;

Sergio SeverinoDepartment of Cardiology, Monaldi Hospital, AORN dei Colli, Naples, Italy;

Carlo PallottoSection of Infectious Diseases, Department of Medicine, University of Perugia, Perugia, Italy; Correspondence[email protected]

Nicolina CapoluongoFirst division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Naples, Italy;

Giulia PalmieroFirst division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Naples, Italy;

Mariano BernardoMicrobiology and Virology Unit, Cotugno Hospital, AORN dei Colli, Naples, Italy

Carlo TasciniFirst division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Naples, Italy;

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Author contributions

VA, AR and CT conceived the study; SS, CP, NC and GP collected data; MDL performed in vitro biofilm tests; VA, CP, MDL and CT draft the manuscript; VA, AR, SS e CT revised the manuscript; CT supervised the whole study.

Disclosure statement

CT has received funds for speaking at symposia on behalf of Pfizer, Novartis, Merck, Thermofisher, Gilead, Angelini and Astellas, Correvio. CP has received funds for speaking at symposia on behalf of Merck, Zambon and Angelini.

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Clinical efficacy of amoxicillin/clavulanate plus cefditoren as de-escalation combination therapy for endocarditis due to strongly biofilm-forming Enterococcus faecalis

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Clinical efficacy of amoxicillin/clavulanate plus cefditoren as de-escalation combination therapy for endocarditis due to strongly biofilm-forming Enterococcus faecalis

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