Abstract
Background
This study aimed to estimate the disease burden and describe the clinical presentation, risk factors, and outcome of CAM in a single centre in Iran.
Methods
A case of mucormycosis was defined as one that had clinical and radiological features consistent with mucormycosis along with demonstration of the fungus in tissue via KOH mount/culture/histopathological and molecular examination.
Results
We report 30 cases of COVID-19 associated mucormycosis (CAM). The results of this study showed the affected age group in the range of 40–79 years (median = 65.5; IQR = 5) with women (16/30, 53%) affected more than men (14/30, 47%). Among the fungi recovered, Rhizopus oryzae had the highest frequency (79%). Out of the 30 patients, 28 (93%) patients were diabetic with 24 (80%) patients having other co-morbidities. Headache followed by retro-orbital pain, proptosis/ptosis and rapid diminution of vision was a common sequence of symptoms reported by the majority of cases. Use of mechanical ventilation (58% vs. 6%, p = 0.003), O2 required (92% vs. 50%, p = 0.024), and development of renal dysfunction during hospital stay (17% vs. 0%, p = 0.041) was significantly higher in non-survivors than survivors. Temperature (C°), PR (pulse rate), mean levels of serum creatinine, BUN, troponin, and neutrophils were significantly higher in non-survivors (p < 0.05). Besides, Albumin and PO2 were also significantly higher in survivors than non-survivors.
Conclusion
Despite medical and surgical treatment, the mortality rate among CAM patients is still high. Thus, concerted efforts of revamping surveillance, diagnosis and management, along with public awareness and patient education, are the requisites for managing COVID-19 and mucormycosis.
Acknowledgement
We acknowledge the financial support of the Tehran University of Medical Sciences to this study. Sincere gratitude to all professors and students of parasitology and mycology at the School of Public Health in Tehran University of Medical Sciences, Kashan Shahid Beheshti Hospital.
Ethical statement
The Ethical Clearance Committee of the Iran University of Medical Sciences approved the study under Reference no. IR.TUMS.SPH.REC.1399.329.
Consent to participate
Informed consent was obtained from all individual participants included in the study.
Consent to publication
All co-authors agreed to the submission of the current form of the manuscript.
Authors’ contributions
Study concept and design: S.J.H., M.E. Collecting samples and laboratory work: M.E., A.H.M., S.H.A., H.M., M.M.H., A.H.A., M.G., and H.H.J. Analysis and interpretation of data: S.J.H., A.H.M., A.H.A., O.R. Drafting of the manuscript: O.R., and M.I.G. Critical revision of the manuscript for important intellectual content: O.R., M.I.G., H.M. Statistical analysis: O.R., S.A. All authors reviewed the manuscript.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
All data are presented in the main manuscript.