In vitro bactericidal activity of biosynthesized CuS nanoparticles against UTI-causing pathogens

ABSTRACT

Nanoparticles are playing a vital role in antimicrobials. The culture supernatant of Serratia nematodiphila is used for reduction of copper sulfate into copper sulfide nanoparticles (CuS-NPs). The present study includes characterization of CdS nanoparticles using UV–vis spectrophotometer, size and morphology by SEM and TEM, and compositional analysis by energy-dispersive X-ray analysis (EDX). The CuS nanoparticles are 9–20 nm in size, measured using EM imaging. The antibacterial activity of CuS nanoparticles was analyzed against urinary tract infection (UTI) pathogens such as Escherichia coli, Staphylococcus aureus, Proteus vulgaris, and Klebsiella pneumoniae. CuS-NPs were found to exhibit good bactericidal property against the UTI after completing successful clinical trials.

KEYWORDS:

• Serratia nematodiphila
• CuS nanoparticles
• UTI pathogens
• antimicrobials

Acknowledgments

The authors gratefully acknowledge Inorganic and Nano-Metal Chemistry (STIC), Cochin for providing SEM and EDX, Indian Institute of Technology (IIT) Bombay for TEM facility.