Room temperature synthesis of 3,4-dihydropyrimidin-2(1H)-one using apatite like oxyphosphate

ABSTRACT

An oxyphosphate of formula BiCa₄(PO₄)₃O was prepared and characterized by powder XRD, Fourier transform infrared spectroscopy (FTIR), and SEM-EDAX techniques. The catalytic activity of the synthesized compound was explored in the preparation of 3,4-dihydropyrimidin-2(1H)-one using Biginelli reaction. Influence of parameters such as temperature and solvent on this reaction using this heterogeneous catalyst was studied. A higher yield of 98% of the 3,4-dihydropyrimidin-2(1H)-one was achieved within 120 min of duration at room temperature in the presence of acetic acid (AcOH).

KEYWORDS:

• Biginelli reaction
• phosphates
• 3,4-dihydropyrimidin-2(1H)-one
• acetic acid
• oxyphosphate

Acknowledgments

The authors thank SAIF, Department of chemistry, IITM for SEM-EDAX, ¹H NMR, and HR-Mass. They also thank TBI and Powder XRD lab VIT University, Vellore.