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Articles

DNA interaction and antioxidant studies of ruthenium(II) complexes containing mixed ligands

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Pages 1049-1056 | Received 07 Mar 2016, Accepted 16 Jan 2017, Published online: 06 Mar 2017
 

ABSTRACT

Ruthenium(II) complexes of mixed ligands (benzothiazolyl Schiff base, PPh3, and AsPh3) have been synthesized. Structural features of the ligands and complexes were determined by various physico-chemical and spectral techniques. In order to ascertain the potential of the above-synthesized compounds towards biomolecular interactions, titration experiments involving interaction with calf thymus DNA (CT-DNA) were carried out. A gel electrophoresis pictogram demonstrated the ability of the complexes to cleave the CT-DNA. The ligands and complexes have shown significant antioxidant activity.

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