Synthesis, crystal structure, and insulin-like activity of [N′-(2-hydroxy-3-methoxybenzylidene)-2-methoxybenzohydrazonato](1,10-phenanthroline)oxovanadium(IV) methanol solvate

ABSTRACT

The aroylhydrazone Schiff base ligand N′-(2-hydroxy-3-methoxybenzylidene)-2-methoxybenzohydrazide (H₂L) reacts with VO(acac)₂ and 1,10-phenanthroline (Phen) in methanol to give the complex [N′-(2-hydroxy-3-methoxybenzylidene)-2-methoxybenzohydrazonato](1,10-phenanthroline)oxovanadium(IV) methanol solvate, [V^IVOL(Phen)]·CH₃OH. The structure of the complex was characterized by elemental analyses and IR spectroscopic method in the solid state. Single-crystal X-ray analysis was also performed. The complex crystallized in the triclinic space group P-1, with unit cell dimensions a = 9.220(3) Å, b = 9.382(3) Å, c = 16.593(5) Å, α = 73.900(5)°, β = 78.618(6)°, γ = 84.959(6)°, V = 1351.1(7) ų, Z = 2, R₁ = 0.0837, and wR₂ = 0.0751. The vanadium(V) atom in the complex is six-coordinated with an octahedral geometry. Thermal stability as well as the insulin-like activity of the complex have been determined.

KEYWORDS:

• Vanadium complex
• crystal structure
• aroylhydrazone
• thermal property
• insulin-like activity

Acknowledgments

The authors are grateful to the Natural Science Foundation of Hebei Key Laboratory of Bioinorganic Chemistry and College of Sciences of Agricultural University of Hebei for financial support.

Supplementary material

CCDC 906161 contains the supplementary crystallographic data for the complex. These data can be obtained free of charge via http://www.ccdc.cam.ac.uk/conts/retrieving.html, or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: [phone]; or e-mail: [email protected].