Synthesis, crystal structure and antimicrobial activity of a novel oxidovanadium(V) complex with tridentate Schiff base ligand

Abstract

A novel oxidovanadium complex, [VOLL’]·CH₃OH, where L is the dianionic form of 3-((3-bromo-2-hydroxyphenyl)-{[1-(3-bromo-2-hydroxyphenyl)methylidene]amino}methyl)pentane-2,4-dione (H₂L), L’ is 1,10-phenanthroline, was prepared and characterized by spectroscopic and single crystal X-ray diffraction. The complex crystallizes as the monoclinic space group Cc, with unit cell dimensions a = 18.806(2) Å, b = 14.960(2) Å, c = 12.954(2) Å, β = 123.719(2)°, V = 3031.5(6) ų, Z = 4, R₁ = 0.0638, wR₂ = 0.0825, Goof =1.069. X-ray analysis indicates that the complex is a mononuclear oxidovanadiumm(V) species, with the V atom in octahedral coordination. The complex was evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. Interestingly, the complex has strong activity against S. aureus.

Keywords:

• Schiff base
• vanadium complex
• mononuclear complex
• crystal structure
• antimicrobial activity

Acknowledgment

This work was financially supported by K.C. Wong Magna Fund in Ningbo University, Ningbo natural science fund (project no. 201701HJ-B01019) and College students of science and technology innovation projects in Zhejiang province and Ningbo city (project no. 2017R405008 and 2017YZD001).

Disclosure statement

No potential conflict of interest was reported by the authors.