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Inorganic and Nano-Metal Chemistry Volume 48, 2018 - Issue 10
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Example of square planar copper(II) biuret complex: crystal structure, DNA and protein binding activity and molecular docking study

Niladri BiswasDepartment of Chemistry, West Bengal State University, Kolkata, India;
,
Ankur ChaudhuriDepartment of Microbiology, West Bengal State University, Kolkata, India
,
Sibani ChakrabortyDepartment of Microbiology, West Bengal State University, Kolkata, India
&
Chirantan Roy ChoudhuryDepartment of Chemistry, West Bengal State University, Kolkata, India; Correspondence[email protected]
Pages 495-507 | Received 09 May 2017, Accepted 02 Jan 2019, Published online: 22 Apr 2019
 
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Abstract

One mononuclear Cu(II) complex Cu(L)2 (1) of biuret ligand has been synthesized and characterized by spectroscopic as well as single crystal X-ray diffraction study. The interaction of 1 with CT-DNA, BSA and HSA (bovine serum albumin and human serum albumin) was studied by UV-Vis, fluorescence spectral methods. Theoretical molecular docking studies were also carried out to investigate the interaction of metal complex (1) with CT-DNA. From all the study, it is clear that complex 1 has significant binding ability with CT-DNA and biologically active protein molecules like BSA as well as HSA. High value of intrinsic binding constant suggests classical intercalative binding modes and this intercalative binding modes were also verified by its quenching phenomenon of 1 with both BSA and HSA.

Acknowledgements

C. Roy Choudhury acknowledges DST- FIST (Project No. SR/FST/CSI-246/2012) New Delhi, Govt. of India for instrumental support under capital heads.

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