Abstract
The Schiff base ligand L is developed from furan-2-carboxaldehyde, 4-aminoantipyrine together with 2-aminothiazole. The mixed ligand complexes are developed from the condensation of above Schiff base ligand L , 1,10-phenanthroline as well as metal(II) acetates of Co(II), Ni(II), Cu(II), and Zn(II). The newly produced compounds were characterized using molar conductance, elemental analysis, XRD, mass, UV-Vis, 1H NMR as well as IR spectral techniques. The X band ESR of [CuLphen] complex was recorded at 300 and 77 K. Geometry and Mulliken charge distribution of the L were studied using Density functional theory (DFT). In vitro biological analysis of L and its [CoLphen], [NiLphen], [CuLphen] as well as [ZnLphen] complexes were studied against bacterial variety such as Pseudomonas aeruginosa, Escherichia coli as well as Staphylococcus aureus. The fungal varieties include Aspergillus niger and Candida albicans. The potent DNA cleavage activities of L as well as its complexes were evaluated.
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