Crystal structure and anti-breast cancer activity evaluation of a nanosized bismuth(V)-containing coordination complex based on the F-decorated ligand

Abstract

In the current study, a new heteroleptic triorganobismuth (V) complex with the chemical formula of Bi(phenyl)₃(2,3-dfa)₂ has been successfully prepared by using C donor phenyl ring and O donor 2,3-difluorobenzoic acid (2,3-H₂dfa) ligands, which has been fully characterized by single crystal X‐ray crystallography, elemental analysis, powder X-ray diffraction along with the thermogravimetric analysis. Furthermore, a green hand grinding technique was used to get the nanocrystals of 1 with an average size of 200 nm as revealed via the scanning electron microscopy (SEM). The inhibitory effect of BT474 cells proliferation after nano 1 treatment was detected with CCK-8 assay. The apoptosis of BT474 cells was measured with FITC-Annexin V/PI double staining assay, the influence on ROS accumulation was determined with DCFH-DA staining.

Keywords:

• Coordination complex
• triphenylbismuth
• diflurobenzoic acid
• anticancer activity