Swelling triggered release of cisplatin from gelatin coated gold nanoparticles

Abstract

In the present study gelatin coated-gold nanoparticles were synthesized and release study of the drug cisplatin was carried out in a swelling controlled manner. In-situ method was adopted, for preparing gelatin coated-Au nanoparticles. Prepared nanoparticles were characterized by FTIR, SEM, TEM, XRD, EDAX and In-vitro cytotoxicity techniques. The data of drug release processes were analyzed kinetically using Fickian power law, zero order, first order and Korsmeyer–Peppas models. Fourier transform infrared (FTIR) spectroscopy confirms the interactions between drug and gelatin coated-Au nanoparticles. SEM images showed that the drug loaded nanoparticles have rough and porous surfaces. The particle size, as measured by TEM technique, revealed that the size of cisplatin loaded gelatin coated-Au nanoparticles lies up to about 100 nm. The maximum drug loading was 74.3%. The release of cisplatin could be best described by Korsmeyer–Peppas model as evident from non-Fickian transport mechanisms having the value R² = 0.997, respectively.

Keywords:

• Gelatin
• gold nanoparticles
• cisplatin
• drug delivery
• swelling controlled release

Acknowledgments

The authors wish to acknowledge the Sophisticated Analystical Instrument Facility, IIT Madras, India for SEM and Cochin, India for TEM, XRD, EDAX analysis.

Disclosure statement

No potential conflict of interest was reported by the authors.