Preparation and characterization of a novel Fe₃O₄@PAA@MIL-100(Cr) metal-organic framework for the drug delivery of ciprofloxacin and investigation of its antibacterial activities

Abstract

Metal-organic frameworks are important materials for drug delivery and imaging applications due to their easy surface modifications and porous surfaces. In this work, we used Fe₃O₄@PAA@MIL-100(Cr) MOF as a carrier of ciprofloxacin (CIP). Fourier-transform infrared spectroscopy (FT-IR), ultraviolet-visible spectroscopy (UV-Visible), energy-dispersive X-ray spectroscopy (EDAX), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), and scanning electron microscope (SEM) analysis confirmed the encapsulation of the drug in nanocarrier. The result of this study showed that ciprofloxacin as an antibacterial drug was encapsulated in Fe₃O₄@PAA@MIL-100(Cr) with a drug loading of 50 wt %. Moreover, drug release was done at pH: 7.4 and pH: 5.5 within 3 days which resulted in about 80% release of the drug at pH: 7.4. In addition, the release analysis based on kinetic equations revealed satisfactory results. The surprising antibacterial activities of Fe₃O₄@PAA@MIL-100(Cr) and Fe₃O₄@PAA@MIL-100(Cr)@CIP were tested against Escherichia coli and Staphylococcus aureus bacteria via the disk diffusion method.

Keywords:

• Fe₃O₄@PAA@MIL-100(Cr)
• drug delivery
• MOF
• antibacterial activities
• ciprofloxacin

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Islamic Azad University, Qom Branch, Qom, I. R. Iran, followed by [grant number 2019-2898].