ABSTRACT
Weighing the cumulative odds ratios suitably, a two treatment response adaptive design for phase III clinical trial is proposed for ordinal categorical responses. Properties of the proposed design are investigated theoretically as well as empirically. Applicability of the design is further verified using a data pertaining to a real clinical trial with trauma patients, where the responses are observed in an ordinal categorical scale.
Acknowledgments
The authors thank the anonymous reviewers, the Editor, and the Associate Editor for their insightful comments which led to an improvement over the earlier version of this work.
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No potential conflict of interest was reported by the authors.
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Notes on contributors
Atanu Biswas
Atanu Biswas, is a professor (Higher Academic Grade) in the Applied Statistics Unit at the Indian Statistical Institute, Kolkata, India.
Rahul Bhattacharya
Rahul Bhattacharya, is a professor in the Department of Statistics at the University of Calcutta, Kolkata, India.
Soumyadeep Das
Soumyadeep Das, is an assistant professor in the Department of Statistics at Bidhannagar Government College, Kolkata, India.