Serum microRNA-30c-5p and microRNA-373 expressions as potential biomarkers for Parkinson's disease

Abstract

This study aimed to confirm the use of microRNA (miR)-30c-5p and miR-373 as the potential biomarkers for Parkinson's disease (PD). In this study, 148 patients with PD admitted to our hospital were enrolled as the research group (RG) and 126 physically examined healthy individuals as the control group (CG) between December 2017 and June 2018. Serum miR-30c-5p and miR-373 expressions in both groups were determined by quantitative real-time polymerase chain reaction. Furthermore, the correlation of their expressions with PD severity was determined by Spearman's correlation analysis. Serum miR-30c-5p and miR-373 expressions were higher in RG than in CG (both P < 0.001). Their expressions were not related to smoking history and diabetes mellitus history in RG (both P>0.001) but were related to sex, age, coronary heart disease history, depression history, and Hoehn–Yahr score (all P < 0.05). Moreover, the relative expressions of serum miR-30c-5p and miR-373 were positively correlated with PD severity (P < 0.05). MiR-30c-5p and miR-373 may be involved in PD development and progression and can be adopted as potential biomarkers for PD.

KEYWORDS:

• MiR-30c-5p
• miR-373
• Parkinson’s disease
• quantitative real-time polymerase chain reaction

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data used to support the findings of this study are available from the corresponding author upon request.

Additional information

Funding

This work was supported by the China–Japan Friendship Hospital under grant number 2018-2-QN-34.