https://orcid.org/0000-0002-0811-6222
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Abstract
LUM, a less-explored member of small leucine-rich proteoglycan family, has gained growing concern with controversial roles in tumor prognosis in recent years. The function of LUM in gastric cancer remains rarely reported and largely unclear. In this study, we investigated the expression of LUM in gastric cancer as well as its association with clinical parameters. Data from the GEO and Human Protein Atlas (HPA) databases are used for further validation. GC tissue shows significantly high expression of LUM compared with normal tissue (P < 0.001). High expression of LUM is correlated with poor differentiation, advanced tumor stage, deeper local invasion and worse overall survival. Patients with high expression of LUM have significantly worse prognosis than those with low expression. Multivariate analysis shows that high expression of LUM is an independent risk factor for overall survival. Several biomolecular pathways, including extracellular matrix receptor interaction, melanoma, cancer, chemokine signaling, Toll-like receptor signaling and Wnt signaling, are screened out as significantly enriched in GCs with high LUM expression using GSEA. Our study reveals that LUM, as an independent predictor, is highly expressed and associated with clinicopathologic factors in gastric cancer, demonstrating potential applications in prognosis of patient with gastric cancer.
Acknowledgements
The authors extend deepest appreciation to Dr Huang Yingshi for editing the manuscript.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data accessibility
The datasets or profiles used in the current study are from TCGA and GEO databases, which are available at the following websites:
https://portal.gdc.cancer.gov/repository