Abstract
Aim: To quantitatively analyze the vascular and structure abnormalities in the papillary areas in eyes with noninfectious uveitis during different periods using optical coherence tomography angiography (OCTA). Methods: Forty eyes of 40 uveitis patients in the acute phase, 12 eyes of 12 patients with inactive uveitis and 21 eyes of 21 healthy controls were included in this study. RPCvd% and pRNFL thickness in different regions were automatically measured and calculated by OCTA. Correlation between RPCvd% and pRNFL was assessed. Results: RPCvd% was significantly higher in uveitis-inactive eyes than in active eyes in the inferior quadrant (p = 0.036), whole image (p = 0.041) and inferior nasal (p = 0.001) sector. The RPCvd% in active uveitis eyes was lower compared to healthy eyes in the inside disc sector (p = 0.026). pRNFL was notably greater in the active group compared to the healthy group. Positive correlations were identified between pRNFL and RPCvd% both in active and inactive uveitis eyes. Conclusions: Compared with active uveitis, papillary microcirculation showed a significant improvement in inactive uveitis eyes (anterior or pan-uveitis). RPCvd% may serve as a sensitive indicator to supervising uveitis progression and treatment response using OCTA.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Competing interests
The authors declare that they have no competing interests.
Authors’ contributions
Both authors have participated directly in planning and execution of the work and have approved the final version of the manuscript. YX: acquisition and analysis of data, drafting and writing the article; XZ: participated in the design of the study, analysis of data, and revised the article critically for important intellectual content.
Availability of data and materials
The data that support the findings of this study are available at https://doi.org/10.6084/m9.figshare.22503784.v1.