Polymorphism of ERK/PTPRR Genes in Major Depressive Disorder at Resting-State Brain Function

ABSTRACT

The polymorphism of ERK and PTPRR in MDD is rarely reported. The present study investigated the association between the polymorphism of ERK/PTPRR and MDD at resting-state brain function using genomic imaging. It indicated that the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) in functional magnetic resonance imaging (fMRI) changed significantly in various brain regions of MDD patients. The T/G allele of ERK-rs1267842 and G/C allele of PTPRR-rs1513105 showed abnormal ALFF and ReHo changes in cortex including superior frontal gyrus and middle temporal gyrus. The development of MDD may be related with the polymorphism of ERK-rs12678428 and PTPRR-rs1513105.

Funding

This study was supported by the National Natural Science Foundation of China (81471379, 81171290), the Scientific and Technological Project of Shanxi Province (20130313023-2), the Health and Family Planning Commission research project in Shanxi Province (2014037), and special funds from the Wu Jieping Medical Foundation of Clinical Research (320.6750.15062).

Additional information

Funding

This study was supported by the National Natural Science Foundation of China (81471379, 81171290), the Scientific and Technological Project of Shanxi Province (20130313023-2), the Health and Family Planning Commission research project in Shanxi Province (2014037), and special funds from the Wu Jieping Medical Foundation of Clinical Research (320.6750.15062).