Prevalence and severity of coronary artery disease in diabetic patients with aortic valve calcifi cation

Abstract

Objective Aortic valve calcifi cation (AVC) is common in the elderly and associated with increased cardiovascular mortality, while diabetes is one of the confi rmed risk factors for coronary artery disease (CAD). In this study, we aimed to evaluate the prevalence and severity of CAD in type-2 diabetic patients with AVC.

Methods From June to December in 2007, a total of 325 consecutive patients with chest pain or chest distress were admitted for coronary angiography. The severity of CAD was evaluated by the Gensini score and the number of stenosed vessels. All patients underwent transthoracic echocardiography for detecting AVC.

Results Compared with the patients without diabetes (n = 221), the type-2 diabetic patients (n = 104) had a similar prevalence of CAD (66.5% vs. 72.1%, P= 0.312). Further classifi ed by the presence of AVC, patients with AVC had a higher prevalence of CAD, average Gensini score and the number of stenosed vessels, both in the group with and without diabetes. It was also demonstrated that the odds ratio (OR) of AVC for CAD in the diabetic patients was higher than in the non-diabetic ones (3.405 vs 2.515) after chi-square analysis (single-variable). However, at multivariable logistic regression analysis for CAD, the OR of AVC was 3.757 (P= 0.03) in diabetic group, while it did not achieve statistical signifi cance in the non-diabetic group (OR = 2.130, P= 0.074).

Conclusions Type-2 diabetic patients with AVC had a higher prevalence of and more severe CAD.

Key Words:

• Aortic valve calcifi cation
• coronary artery disease
• diabetes
• Gensini score.