The efficacy of tolvaptan as a diuretic for chronic kidney disease patients

Abstract

Background Tolvaptan selectively binds to the vasopressin V2 receptor and inhibits reabsorption of free water. Although its effi cacy for heart failure has been proven, its effi cacy for chronic kidney disease (CKD) patients has not been assessed in detail.

Methods We examined 20 CKD patients (13 men and 7 women) who presented with volume overload and who were administered tolvaptan. We assessed urine volume (UV) and blood biochemistry before administration (d0), 1 day after administration (d1), and 7 to 14 days after administration (d7-14).

Results The mean age was 74.0) 13.1 years. Besides CKD, there were 9, 8, and 5 patients with heart failure, liver failure or liver cirrhosis, and severe oedema, respectively. UV signifi cantly increased from 959.0 ) 503.8 mL/day at d0 to 1605.4 ) 964.0 mL/day at d7-14 (P <0.01). Serum creatinine levels were not exacerbated (3.89) 3.43 mg/dL at d0 and 3.66) 3.02 mg/dL at d7-14). Serum albumin (ALB) levels and urinary protein creatinine ratio (uPCR) did not correlate with UV change. Estimated glomerular fi ltration rate (eGFR) correlated with UV change from d0 to d1 (r = 0.6619, P< 0.01). Serum sodiume levation correlated with increased UV (r = 0.4951, P< 0.05).

Conclusion Tolvaptan is useful to reduce volume overload without exacerbation of the renal function; its eff ect does not depend on ALB or uPCR. The eGFR correlated with the effi cacy of tolvaptan. If UV increases drastically after tolvaptan administration, serum Na levels should be carefully monitored.

Key Words:

• Chronic kidney disease
• CKD
• tolvaptan
• diuretic