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Drug Delivery Volume 10, 2003 - Issue 4
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Research Article

Development and Physical Characterization of Sorbitan Monoester Niosomes for Insulin Oral Delivery

Jaleh Varshosaz Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
,
Abbas Pardakhty Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
,
Val-iollah Hajhashemi Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
&
Abdolhossein Rouholamini Najafabadi Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran, Iran
Pages 251-262 | Published online: 31 Jan 2011
 
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Abstract

Niosomes of sorbitan monoesters (Span 20, 40, 60, and 80) were prepared using the film hydration method without sonication. Unlike the other surfactants, Span 80 did not form niosomes in the absence of a sufficient amount of cholesterol. The size of vesicles depended on the cholesterol molar ratio or charge incorporation. The amount of insulin released in simulated intestinal fluid from Span 40 and 60 was lower than Span 20 and 80 vesicles. Vesicles containing Span 60 showed the highest protection of insulin against proteolytic enzymes and good stability in the presence of sodium desoxycholate and storage temperatures.

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