40
Views
7
CrossRef citations to date
0
Altmetric
(RG) Obstetrics and Gynaecology

Immunology and progestins in pregnancy

Pages 47-50 | Published online: 28 Aug 2009
 

Abstract

The relationship between corpus luteum progesterone and rate of abortion is well known. Measurements of progesterone and clinical observations can demonstrate that low serum progesterone levels indicate, even better than human chorionic gonadotropin (hCG) measurements ,an abnormal course of pregnancy. Early substitution seems to be the decisive therapeutic step. In relation to the concentration at the fetomaternal interphase progesterone leads to direct and indirect suppression of T-cell reactions. Progesterone acts synergistically with prostaglandin E2 immunosuppressive. Interleukin-2-induced cellular cytotoxicity is suppressed. Progesterone induces a number of proteins such as PP14 ,which inhibit the activity of T-cells and natural killer cells. Mitogenic lymphocyte reactivity is lowered. To date ,results of immunological therapies do not prove the effectiveness of immunological treatment modalities.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.