Graphical Abstracts

Graphical Abstract Section

Abstract

Synth. Commun. 2005, 35, 2231

DOWEX POLYMER–MEDIATED PROTECTION OF CARBONYL GROUPS

Khodabakhsh Niknam,¹ Ali Reza Kiasat,² and Sadegh Karimi¹

¹Chemistry Department, Faculty of Sciences, Persian Gulf University, Bushehr Iran

²Chemistry Department, College of Science, Shahid Chamran University, Ahvaz, Iran

Dowex (strongly acidic cationic exchange resin) polymer is employed as solid acid catalyst for the clean and less hazardous protection of carbonyl compounds as phenylhydrazones and 2,4-dinitrophenylhydrazones in ethanol under reflux conditions. The reactions proceed very smoothly and the yields of the derivatives are excellent

Abstract

Synth. Commun. 2005, 35, 2237

SUPPORTED TETRAMETHYLAMMONIUM NITRATE/SILICASULFURIC ACID AS A USEFUL REAGENT FOR NITRATION AROMATIC COMPOUNDS UNDER SOLVENT-FREE CONDITIONS

Abdol R. Hajipour,¹ Amin Zarei,¹ Leila Khazdooz,¹ and A. E. Ruoho²

¹Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran

²Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin, USA

A variety of aromatic compounds are nitrated to the parent nitro aromatic compounds under solvent-free conditions using supported tetramethylammonium nitrate/silicasulfuric acid as a useful reagent.

Abstract

Synth. Commun. 2005, 35, 2243

MICROWAVE-ASSISTED SYNTHESIS OF QUINOLINE DERIVATIVES FROM ISATIN

El Sayed H. El Ashry, El Sayed Ramadan, Hamida Abdel Hamid, and Mohamed Hagar

Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt

MWI mixture of isatin 1, ketones, and ethanolic solution of KOH gave quinoline-4-carboxylic acids 2. The MWI was also used for the esterification of 2 and subsequent hydrazinolysis to give 3.

Abstract

Synth. Commun. 2005, 35, 2251

HETEROCYCLIC SYNTHESIS WITH NITRILES: SYNTHESIS OF SOME NEW THIOPHENE, PYRIDAZINE, OXAZINE, THIOPYRAN, PYRROLE, AND PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES

Fathy M. Abdelrazek

Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt

Abstract

Synth. Commun. 2005, 35, 2259

NITROIMIDAZOLE, PART 1. AN UNEXPECTED REACTIVITY DURING THE CYCLIZATION OF 3-(4-AMINO-1-BENZYL-2-ETHYL-1H-IMIDAZOLE-5-YL SULFANYL)-PROPIONIC ACID METHYL ESTER

Yaseen A. Al-Soud¹ and Najim A. Al-Masoudi²

¹Department of Chemistry, College of Science, University of Al a-Bayt, Al-Mafraq, Jordan

²Formerly Fakultät für Chemie, Universität Konstanz, Konstanz, Germany

The action of base on the 5-amino-2,3,4-trisubstituted imidazole, obtained subsequently from the 5-bromo-4-nitro analogue via two steps, gave the racemic mixture 5a, 5b and not the expected 1,3,8-triaza-azulen-7-one deriviative 6.

Abstract

Synth. Commun. 2005, 35, 2265

IMPROVED EXPERIMENTAL PROCEDURE FOR THE SYNTHESIS OF THE POTENT MEK INHIBITOR PD184352

Natalia Shpiro and Rodolfo Marquez

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, Scotland, UK

An improved synthesis of the potent MEK inhibitor PD184352 [2-(2-chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide] is herein reported. This new and reproducible protocol provides a simple and efficient way of generating gram quantities of PD184352 with minimal purification.

Abstract

Synth. Commun. 2005, 35, 2271

SODIUM BOROHYDRIDE–SOLID LiClO₄: AN EFFECTIVE REAGENT FOR REDUCING ALDEHYDES AND KETONES IN APROTIC SOLVENT

Azim Ziyaei Halimjani and Mohammad R. Saidi

Department of Chemistry, Sharif University of Technology, Tehran, Iran

Abstract

Synth. Commun. 2005, 35, 2277

STEREOSELECTIVE SYNTHESIS OF α,α′-SPIRANE-BRIDGED DIBENZYL LIGANDS

Guixian Hu, Christian Rømming, and Kjell Undheim

Department of Chemistry, University of Oslo, Norway

Abstract

Synth. Commun. 2005, 35, 2289

ASYMMETRIC SYNTHESIS OF β‐DDB THROUGH OXAZOLINE‐MEDIATED ULLMANN COUPLING

Qitao Tan, Hongyan Li, Jiwu Wen, Chen Jiang, Xin Wang and Tianpa You

Department of Chemistry, Univeristy of Science and Technology of China Hefei, Anhui, P.R. China

Abstract

Synth. Commun. 2005, 35, 2297

ROSE OXIDES: A FACILE CHEMO AND CHEMO-ENZYMATIC APPROACH

Subhash C. Taneja, Vijay K. Sethi, Samar S. Andotra, Surrinder Koul, and Ghulam N. Qazi

Bio-Organic Chemistry Unit, Regional Research Laboratory (CSIR), Jammu Tawi, India

Abstract

Synth. Commun. 2005, 35, 2305

REGIOSELECTIVE ALKYLATION OF THIAZOLYLSULFONAMIDES: DIRECT AND EFFICIENT SYNTHESIS OF 3-ALKYLTHIAZOLIDENE DERIVATIVES

Naoyuki Masuda, Osamu Yamamoto, Masahiro Fujii, Tetsuro Ohgami, Ayako Moritomo, Toru Kontani, Shunji Kageyama, and Mitsuaki Ohta

Institute for Drug Discovery Research, Astellas Pharma Inc., Japan

Various N-3-alkylated thiazolidenesulfonamide derivatives were efficiently prepared by the direct endo-selective alkylation of thiazolylsulfonamides using NaH–THF combination.

Abstract

Synth. Commun. 2005, 35, 2317

CONTROLLED SYNTHESIS OF 2-ACETYL-6-CARBETHOXYPYRIDINE AND 2,6-DIACETYLPYRIDINE FROM 2,6-DIMETHYLPYRIDINE

Biyun Su,¹ Jianshe Zhao,¹ Yong Cui,² Yongqing Liang,¹ and Wenhua Sun²

¹Shaanxi Key Laboratory of Physico-Inorganic Chemistry, Department of Chemistry, Northwest University, Xi'an 710069, China

²State Key Laboratory of Engineering Plastics and the Center for Molecular Science, Institute of Chemistry, The Chinese Academy of Sciences, Beijing, China

Abstract

Synth. Commun. 2005, 35, 2325

CeCl₃·7H₂O-KI-CATALYZED, ENVIRONMENTALLY FRIENDLY SYNTHESIS OF N,N′-DISUBSTITUTED UREAS IN WATER UNDER MICROWAVE IRRADIATION

Zheng Li, Zhi-Yuan Wang, Wei Zhu, Yu-Lin Xing, and Yan-Long Zhao

Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, 730070, P. R. China

N,N′-Disubstituted ureas were efficiently synthesized by reactions of urea with a variety of amines in water under microwave irradiation using CeCl₃·7H₂O-KI as catalyst.

Abstract

Synth. Commun. 2005, 35, 2333

FIRST EXAMPLE OF TRANSITION-METAL-FREE GLASER-TYPE COUPLING REACTION

Jincan Yan¹ and Lei Wang^1,2

¹Department of Chemistry, Huaibei Coal Teachers College, Huaibei, Anhui, China

²State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

In the presence of potassium tert-butoxide and in toluene, 1,1-dibromo-1-alkenes smoothly generated the corresponding Glaser-type coupling-reaction products (1,3-diynes) in moderate to good yields.

Abstract

Synth. Commun. 2005, 35, 2339

SOLID-STATE CONDENSATION REACTIONS BETWEEN ALDEHYDES AND 5,5-DIMETHYL-1,3-CYCLOHEXANEDIONE BY GRINDING AT ROOM TEMPERATURE

Tong-Shou Jin, Jian-She Zhang, Ai-Qing Wang, and Tong-Shuang Li

¹Department of Chemistry, College of Chemistry and Environmental Science, Hebei University, Baoding, Hebei Province, China

An efficient and convenient approach to the synthesis of the two different products from aldehydes and 5,5-dimethyl-1,3-cyclohexanedione in the solid state by grinding is described.

Abstract

Synth. Commun. 2005, 35, 2347

CONVENIENT AND EFFICIENT SYNTHESIS OF 1,1-BIS-(4-ALKYLTHIOPHENYL)-1-ALKENES VIA TANDEM FRIEDEL–CRAFTS ACYLATION AND ALKYLATION OF SULFIDES AND ACYL CHLORIDES

Jiaxi Xu, Jiakun Xia, and Yu Lan

Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China

1,1-Bis(4-alkylthiophenyl)-1-alkenes were conveniently and efficiently prepared from alkyl phenyl sulfides and acyl chlorides via a tandem Friedel–Crafts acylation and alkylation in the presence of anhydrous aluminum chloride. The scope, limitation, and mechanism of the tandem reaction were also discussed.