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Abstract
ULTRASOUND‐PROMOTED MAGNESIUM‐AMMONIUM BROMIDE–MEDIATED PINACOL COUPLING OF AROMATIC ALDEHYDES AND KETONES
Ji‐Tai Li, Yan‐Xue Chen, and Tong‐Shuang Li
College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding, China
Pinacol coupling of aromatic aldehydes and ketones by Mg powder in 0.1‐M ammonium bromide aqueous solution can lead to the corresponding pinacols in 22–90% yields within 1–3 h at rt under ultrasound irradiation.
Abstract
CONVENIENT ONE‐POT SYNTHESIS OF ALKYL VINYL ETHERS FROM PHENYL 2‐HYDROXYALKYL SELENIDES
Shou‐Ri Sheng, Hai‐Rong Luo, Wu‐Kang Sun, Xiao‐Ling Liu, Qin Xin, and Qiu‐Ying Wang
College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, China
O‐alkylation of phenyl 2‐hydroxyalkyl selenides with primary or secondary organic halides was carried out and subsequent oxidation elimination furnished vinyl ethers with good yields in a one‐pot, two‐step transformation.
Abstract
TRANSAMIDATION CATALYZED BY A RECOVERABLE AND REUSABLE POLYDMAP‐BASED HAFNIUM CHLORIDE AND MONTMORILLONITE KSF
Min Shi and Shi‐Cong Cui
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
An easily available and reusable polymer‐based hafnium chloride and montmorillonite KSF catalyst (HfCl4/KSF‐polyDMAP) can be used in transamidation under relatively mild conditions.
Abstract
TANDEM OXIDATION SEQUENCE TO PREPARE ETHYL (E)‐4,5‐DIOXO‐2‐HEXADECENOATE: A FORMAL SYNTHESIS OF PODOSCYPHIC ACID
Cecilia Devi Wilfred and Richard J. K. Taylor
Department of Chemistry, University of York, Heslington, York, UK
Tandem oxidation methodology has been utilized to prepare ethyl (E)‐4,5‐dioxo‐2‐hexadecenoate, the immediate precusor to the antiviral metabolite podoscyphic acid.
Abstract
HIGHLY REGIOSELECTIVE ONE‐POT SYNTHESIS OF 7‐HYDROXY‐6‐METHYLPHTHALIDE FROM 3‐HYDROXY‐4‐METHYLBENZYLALCOHOL
Meili Duan and Michael D. Toney
Department of Chemistry, University of California at Davis, Davis, California, USA
Abstract
MONTMORILLONITE K10 CLAY: AN EFFECTIVE SOLID CATALYST FOR ONE‐POT SYNTHESIS OF POLYHYDROQUINOLINE DERIVATIVES
Guoyong Song,1,2 Bo Wang,1,2 Xiaoyin Wu,3 Yuru Kang,1 and Liming Yang1
1State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China
2Graduate School of Chinese Academy of Sciences, Beijing, China
3College of Earth and Environment Sciences, Lanzhou University, Lanzhou, China
An efficient one‐pot four‐component coupling process for the synthesis of polyhydroquinoline derivatives catalyzed by montmorillonite K10 clay is described for the first time.
Abstract
A NEAT AND RAPID SYNTHESIS OF 2‐ARYLOXYMETHYLENE‐6‐ARYLIMIDAZO[2,1‐b]‐1,3,4‐THIADIAZOLE UNDER MICROWAVE IRRADIATION
Xicun Wang, Mangang Wang, Zhengjun Quan, and Zheng Li
Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, China
A neat and rapid procedure is reported for the synthesis of a variety of 2-aryloxymethylene-6-arylimidazo[2,1-b]-1,3,4-thiadiazole (3a–3r) by condensation reaction of 2-amino-5-aryloxymethylene-1,3,4-thiadiazole (1a–1f) with ω-bromoacetophenone (2a–2c) in ethanol solvent under microwave irradiation.
Abstract
SIMPLE AND FACILE TETRAHYDROPYRANYLATION OF ALCOHOLS BY USE OF CATALYTIC AMOUNT OF BENZYLTRIPHENYLPHOSPHONIUM TRIBROMIDE
A. R. Hajipour,1,2 S. A. Pourmousavi,1 and A. E. Ruoho2
1Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan, Iran
2Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin, USA
An efficient and mild system for protection of a variety of alcohols with 3,4‐dihydro‐2H‐pyran (DHP) in the presence of catalytic amounts of benzyltriphenylphosphonium tribromide (BTPTB).
Abstract
SYNTHESIS OF NOVEL ASYMMETRICAL 1,4‐DIHYDROPYRIDINE DERIVATIVES
Adeleh Moshtaghi Zenouz, Mina Raisossadat Oskuie, and Shirin Mollazadeh
Chemistry Department, Faculty of Science, Azarbaijan University of Tarbiat Moallem, Tabriz, Iran
Abstract
SOLVENT‐FREE CONVERSION OF ALCOHOLS INTO IODIDES WITH NAI SUPPORTED ON KSF CLAY
Mahmood Tajbakhsh1, Rahman Hosseinzadeh1, Zahra Lasemi1, and Ali Rostami2
1Department of Chemistry, Mazandaran University, Babolsar, Iran 2Department of Chemistry, University of Alberta, Edmonton, Canada
NaI supported on KSF clay provides an efficient, mild, selective, and economical method for the iodination of aliphatic, allylic, and benzylic alcohols.
Abstract
(NO3)3CeBrO3: SOLVENT‐FREE OXIDATION OF ALCOHOLS AND DEPROTECTION AND OXIDATIVE DEPROTECTION OF TRIMETHYLSILYL ETHERS
Farhad Shirini,1 Majid Esm‐Hosseini,2 and Zoha Hejazi1,2
1Department of Chemistry, Guilan University, Rasht, Iran
2Department of Chemistry, Urmia University, Urmia, Iran
Trinitratocerium(IV) bromate (TNCB) can be used as an efficient reagent for oxidation of alcohols and deprotection and oxidative deprotection of trimethylsilyl ethers under solvent‐free conditions.
Abstract
SHORT SYNTHESIS OF FUNCTIONALIZED CYCLIC HOMOALLYLSILANES
Rim Ouled Saad, Taoufik Turki, and Hassen Amri
Laboratoire de Chimie Organique et Organométallique, Tunis, Tunisia
A convenient synthesis of functionalized cyclic homoallylsilanes 5 and 6 from allylic acetates 3 and 4 is reported.
Abstract
SYNTHESIS OF H‐PHOSPHINATES BY THE UV LIGHT–MEDIATED FRAGMENTATION‐RELATED PHOSPHORYLATION USING SIMPLE P‐HETEROCYCLES
H. Szelke,1 J. Kovács,2 and Gy. Keglevich2
1Research Group of the Hungarian Academy of Sciences at the Department of Organic Chemical Technology, Budapest University of Technology and Economics, Budapest, Hungary
2Department of Organic Chemical Technology, Budapest University of Technology and Economics, Budapest, Hungary
A variety of substituted five‐membered P‐heterocycles can be utilized in the title reaction to afford H‐phosphinates [YP(O)(OMe)H].
Abstract
FACILE AND CHEMOSELECTIVE REDUCTION OF CARBOXYLIC ACIDS INTO ALCOHOLS VIA SODIUM BOROHYDRIDE REDUCTION OF N‐ACYLBENZOTRIAZOLES
Kamal Nain Singh and Amarjit Kaur
Department of Chemistry, Punjab University, Chandigarh, India
Carboxylic acids are converted into corresponding alcohols by chemoselective reduction of their benzotriazole amides with sodium borohydride.
Abstract
EFFICIENT ONE‐STEP SYNTHESIS OF A KEY INTERMEDIATE FOR THE SYNTHESIS OF AZOLE ANTIFUNGALS USING THE MITSUNOBU PROTOCOL
Jitendra A. Sattigeri,1 Jasbir S. Arora,1 Ashwani K. Verma,1 Sanjay Malhotra,1 and Mohammad Salman1
1Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratory, Haryana, India
We describe herein a new simple and single‐step process for the synthesis of key intermediate 4a for the synthesis of azole antifungals using the Mitsunobu protocol.
