ELECTROCHEMICAL OXIDATION OF MELOXICAM AND ITS DETERMINATION IN TABLET DOSAGE FORM

Abstract

The oxidative voltammetric behavior of meloxicam at a carbon paste electrode has been studied in Britton-Robinson buffers in the pH range of 2.0–11.5. Meloxicam gave rise to two voltammetric peaks, corresponding to the oxidation of amide and enol functions, respectively. The oxidation process was found to be dependent on the pH of the supporting electrolyte. Using linear-scan voltammetry, the drug yielded well-defined voltammetric response in Britton-Robinson buffer of pH 3.0. The process could be used to determine meloxicam concentration in the range 5.0 × 10⁻⁷ − 5 × 10⁻⁵M with detection limit of 1.6 × 10⁻⁷M. Application of the method to the determination of the drug in the dosage form, without any interference from the excipients, resulted in acceptable deviation from the stated concentration (RSD = 2.2 %).

Keywords:

• Meloxicam
• Linear-scan voltammetry
• Formulation analysis

Acknowledgments