COMPARATIVE EVALUATION OF ANALYTICAL METHODS FOR SIMULTANEOUS DETERMINATION OF NISOLDIPINE AND ITS PHOTODEGRADATION PRODUCTS

ABSTRACT

Simultaneous determination of Nisoldipine and two photolytic products in pharmaceutical preparations and raw material was performed by two spectrophotometric methods, utilizing a derivative procedure and a multivariate analysis based on classical least square algorithm. In order to improve the prediction ability of CLS analysis, a selection procedure of the useful wavelengths has been performed. Both methods were compared with a conventional gas chromatographic method. The recovery values were estimated to be within 96 and 106% and RSD values below 5%. The LOD for both photoproducts was 1%.

Keywords:

• Nisoldipine
• Photodegradation
• Derivative spectrophotometry
• UV Multivariate analysis
• Gas chromatography

ACKNOWLEDGMENTS

This research was supported by grants from M.U.R.S.T. (Italy).