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Abstract
An adsorptive stripping voltammetric procedure for the determination of the antidepressant venlafaxine in urine using a mercury film microelectrode was developed. The method is based on controlled adsorptive accumulation of the drug at the potential of −1.00 V (vs. Ag/AgCl) in the presence of 1.25 × 10−2 mol L−1 borate buffer (pH 8.7). Urine samples were analyzed directly after performing a ten-fold dilution with the supporting electrolyte but without other pretreatment. The limit of detection obtained for a 30 s collection time was 0.693 × 10−6 mol L−1. Recovery experiments gave good results at the 10−6 mol L−1 level (bias less 5% were obtained).
