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PHARMACEUTICAL ANALYSIS

Simple, Rapid, and Sensitive Spectrofluorimetric Determination of Zaleplon in Micellar Medium

, , , , , & show all
Pages 2985-2997 | Received 14 May 2003, Accepted 10 Aug 2003, Published online: 02 Feb 2007
 

Abstract

The influence of micellar medium on the absorption, fluorescent excitation and emission spectra character of Zaleplon was studied. The nonionic surfactant of Triton X-100 showed a strong sensitizing effect for the fluorescence of Zaleplon in a pH 5.0 buffer. The possible enhancement mechanism was discussed. Based on the optimum conditions, a simple, rapid, sensitive and selective spectrofluorimetric method (λexem = 345/455 nm) has been developed for the determination of Zaleplon. The linear range was 1.32 × 10−8–1.00 × 10−5  mol/L. The detection limit was 4.0 × 10−9 mol/L with an RSD of 0.06%. The proposed method was successfully applied to the determination of Zaleplon in tablets, serum and urine.

Acknowledgment

This work was supported by the Importance Natural Science Foundation of Shandong Province in China (no. Z2000B03).

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