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Pharmaceutical Analysis

Membrane Preconcentration of Nalidixic and Piromidic Acids and Simultaneous Determination Using a Synchronous Solid‐Phase Phosphorescence Approach

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Pages 2669-2683 | Received 16 Apr 2004, Accepted 25 Jun 2004, Published online: 02 Feb 2007
 

Abstract

A preconcentration membrane for the retention and phosphorimetric determination of pharmaceuticals nalidixic and piromidic acids is proposed. The membrane has a circular zone of plasticized PVC adhered to the surface of a polyester strip, which constitutes the preconcentration area where the analytes are retained by absorption from a solution that contains it. Measurement of intrinsic phosphorescence in the synchronous phosphorescence spectra performed at 281/371 nm for nalidixic acid and 331/471 nm for piromidic acid make the resolution of the mixture possible. The applicable concentration range, detection limit, and precision (as relative standard deviation) are from 0.3 to 3.0 mg · l−1, 0.08 mg · l−1, and 5.1% for nalidixic acid and from 0.03 to 0.15 mg · l−1, 0.002 mg · l−1, and 5.2% for piromidic acid. The method was applied to the determination of residues of both pharmaceuticals in cow milk and human urine.

Acknowledgements

We acknowledge financial support from the Ministerio de Educación y Cultura, Dirección General de Enseñanza Superior (Spain) (Project No. BQU2002‐00353) and Plan Propio de la Universidad de Granada (2002‐30PP000500).

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