![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
Two enantioselective, potentiometric membrane electrodes were proposed for the assay of R‐baclofen. The electrodes were designed using a macrocyclic glycopeptide antibiotic, teicoplanin. Acetonitrile was added to the teicoplanin to design a modified teicoplanin‐based electrode. The linear concentration ranges for the proposed enantioselective, membrane electrodes were 10−7–10−4 mol/L for teicoplanin‐based electrode and 10−6–10−4 mol/L for the electrode based on teicoplanin modified with acetonitrile. The slopes of the electrodes were 60.0 mV/pR‐baclofen and 57.2 mV/pR‐baclofen for teicoplanin and teicoplanin modified with acetonitrile‐based electrodes, respectively. The enantioselectivity was determined over S‐baclofen. The proposed electrodes can be employed reliably for the assay of R‐baclofen raw material and from its pharmaceutical formulation, Norton‐Baclofen® tablets. The surfaces of the electrodes are stable and easily renewable by polishing on alumina paper.