Flow Injection Potentiometric Determination of Dothiepin Hydrochloride

Abstract

New plastic membrane electrodes for dothiepin hydrochloride (DpCl) based on dothiepin phosphotungstate (Dp‐PTA), dothiepin phosphomolybdate (Dp‐PMA), and a mixture of both (Dp‐PTA/PMA) were prepared. The electrodes were fully characterized in terms of their composition, life span, pH, and temperature, and then were applied to the potentiometric determination of the dothiepinium ion in its pure state and pharmaceutical preparations in batch and flow injection conditions. The selectivity of the electrodes toward many inorganic cations, sugars, and amino acids was also tested.